Inpp5f - inositol polyphosphate-5-phosphatase F Gene

Also Known as SAC2; cI-27; hSAC2; mKIAA0966; 5830435P03Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 101490

Summary

Enables inositol monophosphate 4-phosphatase activity and phosphatidylinositol phosphate 4-phosphatase activity. Involved in several processes, including negative regulation of axon regeneration; phosphatidylinositol dephosphorylation; and positive regulation of receptor recycling. Acts upstream of or within cardiac muscle hypertrophy in response to stress; phosphatidylinositol catabolic process; and phosphatidylinositol-mediated signaling. Located in several cellular components, including cytoplasmic vesicle; dendrite; and neuronal cell body. Is expressed in several structures, including brain; genitourinary system; heart; retina; and spleen. Orthologous to human INPP5F (inositol polyphosphate-5-phosphatase F). [provided by Alliance of Genome Resources, Apr 2022]

Inpp5f Products (2)

mRNA	Protein	Name
NM_001346517.1	NP_001333446.1	phosphatidylinositide phosphatase SAC2 isoform 2
NM_178641.5	NP_848756.2	phosphatidylinositide phosphatase SAC2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables inositol monophosphate 4-phosphatase activity	IDA IDA: Inferred from direct assay	25869669	MGI
enables phosphatidylinositol phosphate 4-phosphatase activity	IDA IDA: Inferred from direct assay	25869669	MGI
enables phosphatidylinositol phosphate 4-phosphatase activity	IMP IMP: Inferred from mutant phenotype	25869668	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	25869668	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in adult locomotory behavior	IMP IMP: Inferred from mutant phenotype	26203138	MGI
acts upstream of or within cardiac muscle hypertrophy in response to stress	IMP IMP: Inferred from mutant phenotype	19875726	MGI
involved in clathrin-dependent endocytosis	IDA IDA: Inferred from direct assay	25869668	MGI
involved in negative regulation of axon regeneration	IMP IMP: Inferred from mutant phenotype	26203138	MGI
acts upstream of or within phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	19875726	MGI
acts upstream of or within phosphatidylinositol catabolic process	IMP IMP: Inferred from mutant phenotype	19875726	MGI
involved in phosphatidylinositol dephosphorylation	IDA IDA: Inferred from direct assay	25869669	MGI
involved in phosphatidylinositol dephosphorylation	IMP IMP: Inferred from mutant phenotype	25869668	MGI
involved in positive regulation of receptor recycling	IMP IMP: Inferred from mutant phenotype	25869669	MGI
involved in regulation of cell motility	IMP IMP: Inferred from mutant phenotype	25869669	MGI
involved in regulation of endocytic recycling	IMP IMP: Inferred from mutant phenotype	25869669	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in axon	IDA IDA: Inferred from direct assay	26203138	MGI
located in clathrin-coated endocytic vesicle	IDA IDA: Inferred from direct assay	25869668	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	26203138	MGI
located in dendrite	IDA IDA: Inferred from direct assay	26203138	MGI
located in early endosome	IDA IDA: Inferred from direct assay	25869668	MGI
located in neuronal cell body	IDA IDA: Inferred from direct assay	26203138	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
phosphatidylinositide phosphatase SAC2	sac domain-containing inositol phosphatase 2 sac domain-containing phosphoinositide 4-phosphatase 2 sac domain-containing phosphoinositide 5-phosphatase 2

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06831	INPP5F Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09746	OCRL Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Inpp5f	NCBI	NCBI:22876