Arhgef18 - rho/rac guanine nucleotide exchange factor (GEF) 18 Gene

Mus musculus

Also known as A430078G23Rik; D030053O22Rik

Gene ID: 102098 | Gene type: protein coding

About Arhgef18

Summary

Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in negative regulation of stress fiber assembly; protein localization to cell-cell junction; and regulation of Rho protein signal transduction. Predicted to act upstream of or within actin Cytoskeleton organization; regulation of cell shape; and small GTPase mediated signal transduction. Predicted to be located in apical part of cell and cytosol. Predicted to be active in plasma membrane. Is expressed in brain; dermis; epidermis; and metanephros. Human ortholog(s) of this gene implicated in retinitis pigmentosa. Orthologous to human ARHGEF18 (Rho/Rac guanine nucleotide exchange factor 18). [provided by Alliance of Genome Resources, Apr 2022]

Arhgef18 Products(2)

mRNA	Protein	Name
NM_001370668.1	NP_001357597.1	rho guanine nucleotide exchange factor 18 isoform 1
NM_133962.4	NP_598723.3	rho guanine nucleotide exchange factor 18 isoform 2

Protein Preferred Names

Protein Names

rho guanine nucleotide exchange factor 18

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00953	ARHGEF18 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Arhgef18	NCBI	NCBI:23370

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