Arhgef18 - rho/rac guanine nucleotide exchange factor (GEF) 18 Gene

Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in negative regulation of stress fiber assembly; protein localization to cell-cell junction; and regulation of Rho protein signal transduction. Predicted to act upstream of or within actin Cytoskeleton organization; regulation of cell shape; and small GTPase mediated signal transduction. Predicted to be located in apical part of cell and cytosol. Predicted to be active in plasma membrane. Is expressed in brain; dermis; epidermis; and metanephros. Human ortholog(s) of this gene implicated in retinitis pigmentosa. Orthologous to human ARHGEF18 (Rho/Rac guanine nucleotide exchange factor 18). [provided by Alliance of Genome Resources, Apr 2022]