Pls1 - plastin 1 (I-isoform) Gene

Species: Mus musculus

Gene Type: protein coding

Gene ID: 102502

Summary

Predicted to enable actin filament binding activity. Involved in several processes, including inner ear receptor cell stereocilium organization; intestinal D-glucose absorption; and positive regulation of protein localization to plasma membrane. Acts upstream of or within terminal web assembly. Located in brush border; stereocilium; and terminal web. Is expressed in egg cylinder; female reproductive system; and gut. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 76. Orthologous to human PLS1 (plastin 1). [provided by Alliance of Genome Resources, Apr 2022]

Pls1 Products (1)

mRNA	Protein	Name
NM_001033210.3	NP_001028382.1	plastin-1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19321664	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in auditory receptor cell stereocilium organization	IMP IMP: Inferred from mutant phenotype	25124451	MGI
involved in intestinal D-glucose absorption	IGI IGI: Inferred from genetic interaction	22114352	MGI
NOT involved in microvillus assembly	IGI IGI: Inferred from genetic interaction	22114352	MGI
involved in positive regulation of multicellular organism growth	IGI IGI: Inferred from genetic interaction	22114352	MGI
involved in positive regulation of protein localization to plasma membrane	IGI IGI: Inferred from genetic interaction	22114352	MGI
involved in positive regulation of protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	22114352	MGI
involved in regulation of microvillus length	IGI IGI: Inferred from genetic interaction	22114352	MGI
involved in terminal web assembly	IGI IGI: Inferred from genetic interaction	22114352	MGI
acts upstream of or within terminal web assembly	IMP IMP: Inferred from mutant phenotype	19321664	MGI
involved in vestibular receptor cell stereocilium organization	IMP IMP: Inferred from mutant phenotype	25124451	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in brush border	IDA IDA: Inferred from direct assay	22114352	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	7655078	MGI
located in stereocilium	IDA IDA: Inferred from direct assay	25124451	MGI
located in terminal web	IDA IDA: Inferred from direct assay	19321664	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
plastin-1	I-fimbrin plastin 1, I

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10739	PLS1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pls1	NCBI	NCBI:5357