2. Gene
  3. Pls1 - plastin 1 (I-isoform) Gene

Pls1 - plastin 1 (I-isoform) Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus
Gene ID: 102502 | Gene type: protein coding

About Pls1

Summary

Predicted to enable actin filament binding activity. Involved in several processes, including inner ear receptor cell stereocilium organization; intestinal D-glucose absorption; and positive regulation of protein localization to plasma membrane. Acts upstream of or within terminal web assembly. Located in brush border; stereocilium; and terminal web. Is expressed in egg cylinder; female reproductive system; and gut. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 76. Orthologous to human PLS1 (plastin 1). [provided by Alliance of Genome Resources, Apr 2022]

Pls1 Products(1)

mRNA Protein Name
NM_001033210.3 NP_001028382.1 plastin-1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
19321664 MGI
Biological Process GO Annotation Evidence Reference Source
involved in auditory receptor cell stereocilium organization IMP
IMP: Inferred from mutant phenotype
25124451 MGI
involved in intestinal D-glucose absorption IGI
IGI: Inferred from genetic interaction
22114352 MGI
NOT involved in microvillus assembly IGI
IGI: Inferred from genetic interaction
22114352 MGI
involved in positive regulation of multicellular organism growth IGI
IGI: Inferred from genetic interaction
22114352 MGI
involved in positive regulation of protein localization to plasma membrane IGI
IGI: Inferred from genetic interaction
22114352 MGI
involved in positive regulation of protein localization to plasma membrane IMP
IMP: Inferred from mutant phenotype
22114352 MGI
involved in regulation of microvillus length IGI
IGI: Inferred from genetic interaction
22114352 MGI
involved in terminal web assembly IGI
IGI: Inferred from genetic interaction
22114352 MGI
acts upstream of or within terminal web assembly IMP
IMP: Inferred from mutant phenotype
19321664 MGI
involved in vestibular receptor cell stereocilium organization IMP
IMP: Inferred from mutant phenotype
25124451 MGI
Cellular Component GO Annotation Evidence Reference Source
located in brush border IDA
IDA: Inferred from direct assay
22114352 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
7655078 MGI
located in stereocilium IDA
IDA: Inferred from direct assay
25124451 MGI
located in terminal web IDA
IDA: Inferred from direct assay
19321664 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

plastin-1

I-fimbrin

plastin 1, I

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10739 PLS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pls1 NCBI NCBI:5357