ST3GAL6 - ST3 beta-galactoside alpha-2,3-sialyltransferase 6 Gene
Also Known as SIAT10; ST3GALVI
Species: Homo sapiens
About ST3GAL6
This gene has 27 transcripts (splice variants), 122 orthologues and 14 paralogues. Broad expression in heart (RPKM 8.2), liver (RPKM 7.6) and 24 other tissues.
Summary
The protein encoded by this gene is a member of the Sialyltransferase family. Members of this family are Enzymes that transfer sialic acid from the activated cytidine 5'-monophospho-N-acetylneuraminic acid to terminal positions on sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins. This protein has high specificity for neolactotetraosylceramide and neolactohexaosylceramide as glycolipid substrates and may contribute to the formation of Selectin ligands and sialyl Lewis X, a carbohydrate important for cell-to-cell recognition and a blood group antigen. [provided by RefSeq, Apr 2016]
ST3GAL6 Products (18)
| mRNA | Protein | Name |
|---|---|---|
| NM_001271142.2 | NP_001258071.1 | type 2 lactosamine alpha-2,3-sialyltransferase isoform 2 |
| NM_001271145.2 | NP_001258074.1 | type 2 lactosamine alpha-2,3-sialyltransferase isoform 3 |
| NM_001271146.2 | NP_001258075.1 | type 2 lactosamine alpha-2,3-sialyltransferase isoform 1 |
| NM_001271147.2 | NP_001258076.1 | type 2 lactosamine alpha-2,3-sialyltransferase isoform 4 |
| NM_001271148.2 | NP_001258077.1 | type 2 lactosamine alpha-2,3-sialyltransferase isoform 5 |
| NM_001323352.2 | NP_001310281.1 | type 2 lactosamine alpha-2,3-sialyltransferase isoform 1 |
| NM_001323353.2 | NP_001310282.1 | type 2 lactosamine alpha-2,3-sialyltransferase isoform 5 |
| NM_001323358.2 | NP_001310287.1 | type 2 lactosamine alpha-2,3-sialyltransferase isoform 7 |
| NM_001323359.2 | NP_001310288.1 | type 2 lactosamine alpha-2,3-sialyltransferase isoform 7 |
| NM_001323360.2 | NP_001310289.1 | type 2 lactosamine alpha-2,3-sialyltransferase isoform 2 |
| NM_001323362.2 | NP_001310291.1 | type 2 lactosamine alpha-2,3-sialyltransferase isoform 5 |
| NM_001323363.2 | NP_001310292.1 | type 2 lactosamine alpha-2,3-sialyltransferase isoform 5 |
| NM_001323364.2 | NP_001310293.1 | type 2 lactosamine alpha-2,3-sialyltransferase isoform 5 |
| NM_001323365.2 | NP_001310294.1 | type 2 lactosamine alpha-2,3-sialyltransferase isoform 1 |
| NM_001323366.2 | NP_001310295.1 | type 2 lactosamine alpha-2,3-sialyltransferase isoform 2 |
| NM_001323367.4 | NP_001310296.2 | type 2 lactosamine alpha-2,3-sialyltransferase isoform 1 |
| NM_001323368.2 | NP_001310297.1 | type 2 lactosamine alpha-2,3-sialyltransferase isoform 1 |
| NM_006100.4 | NP_006091.1 | type 2 lactosamine alpha-2,3-sialyltransferase isoform 1 |
ST3GAL6 Protein Structure
Glyco_transf_29: Glycosyltransferase family 29 (sialyltransferase) (78 - 329)
- 0
- 100
- 200
- 300
- 331 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
type 2 lactosamine alpha-2,3-sialyltransferase |
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Felis catus | ST3GAL6 | VGNC | VGNC:65724 |
| Bos taurus | ST3GAL6 | VGNC | VGNC:35335 |
| Rattus norvegicus | ST3GAL6 | RGD | RGD:1303279 |
| Macaca mulatta | ST3GAL6 | VGNC | VGNC:77951 |
| Canis familiaris | ST3GAL6 | VGNC | VGNC:46854 |
| Mus musculus | ST3GAL6 | MGD | MGI:1888707 |
| Others | ST3GAL6 | NCBI |