MYCNOS - MYCN opposite strand Gene

Homo sapiens

Also known as NCYM; NYCM; N-CYM; MYCN-AS1

Gene ID: 10408 | Gene type: ncRNA

About MYCNOS

Cytogenetic location: 2p24.3 Genomic coordinates (GRCh38): 2:15,936,265-15,942,433 (from NCBI)

This gene has 5 transcripts (splice variants). Low expression observed in reference dataset.

Summary

This gene is transcribed in antisense to the v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog gene (MYCN). It is thought to encode a small, novel protein that stabilizes MYCN, prevents Apoptosis, and promotes cell proliferation. Transcripts at this locus may also act directly as functional RNAs to recruit transcriptional regulators to the promoter of MYCN and stimulate transcription of this oncogene. This gene therefore functions through both RNA and protein products. [provided by RefSeq, Aug 2016]

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	24391509	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of kinase activity	IDA IDA: Inferred from direct assay	24391509	GOA
involved in regulation of protein stability	IMP IMP: Inferred from mutant phenotype	24391509	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	24391509	GOA
located in nucleus	IDA IDA: Inferred from direct assay	24391509	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Related Diseases

Diseases

Alias

Feingold Syndrome 1

Feingold Syndrome	Oculodigitoesophagoduodenal Syndrome
Oded Syndrome	Microcephaly-Oculo-Digito-Esophageal-Duodenal Syndrome
Digital Anomalies With Short Palpebral Fissures And Atresia Of Esophagus Or Duodenum	FGLDS1
Mmt Syndrome	Brunner-Winter Syndrome
Feingold Syndrome Type 1	Oded
Moded	Fglds
Microcephaly-Digital Anomalies-Normal Intelligence Syndrome	Moded Syndrome
Oculo-Digito-Esophageal-Duodenal Syndrome	Microcephaly, Mental Retardation, And Tracheoesophageal Fistula Syndrome
Microcephaly And Digital Abnormalities With Normal Intelligence	Digital Anomalies With Short Palpebral Fissures And Atresia Of Esophagus, Or Duodenum
Microcephaly-Mesobrachyphalangy-Tracheoesophageal Fistula Syndrome	Microcephaly-Oculo-Digito-Esophageal-Duodenal Syndrome
Oculo-Digito-Esophagoduodental Syndrome	Fs
Mmt	Microcephaly-Intellectual Disability-Tracheoesophageal Fistula Syndrome
Microcephaly-Oculo-Digito-Esophageal-Duodenal Syndrome Syndrome	Brunner-Winter Syndrome Type 1
Digital Anomalies With Short Palpebral Fissures And Atresia Of Esophagus Or Duodenum Type 1	Fs1
Mmt Type 1	Moded Syndrome Type 1
Microcephaly-Digital Anomalies-Normal Intelligence Syndrome Type 1	Microcephaly-Intellectual Disability-Tracheoesophageal Fistula Syndrome Type 1
Microcephaly-Oculo-Digito-Esophageal-Duodenal Syndrome Syndrome Type 1	Oded Syndrome Type 1
Oculo-Digito-Esophageal-Duodenal Syndrome Type 1	Feingold Syndrome, Type 1

Neuroblastoma

Nb	Neuroblastoma, Susceptibility To
Neuroblastomas	Central Neuroblastoma

Pancreatic Adenocarcinoma

Adenocarcinoma Of The Pancreas	Adenocarcinoma Of Pancreas
Pancreas Adenocarcinoma	Malignant Exocrine Neoplasm
Primary Pancreatic Adenocarcinoma	Adenocarcinoma Of Islet Cell Of Pancreas
Islet Cell Adenocarcinoma Of Unspecified Site	Mixed Adenocarcinoma Islet Cell With Exocrine Of Unspecified Site

Medulloblastoma

MDB	Cpnet
Localized Primitive Neuroectodermal Tumor	Classic Medulloblastoma
Medulloblastoma Predisposition Syndrome	Medulloblastoma, Somatic
Brain Medulloblastoma	Cns Pnet
Infratentorial Primitive Neuroectodermal Tumor	Neuroectodermal Tumors, Primitive
Medulloblastomas	Desmoplastic Medulloblastoma
Medulloblastoma, With Extensive Nodularity	Medulloblastoma Of Unspecified Site
Medullomyoblastoma Of Unspecified Site

Gliosarcoma

Glioblastoma With Sarcomatous Component

Sarcomatous Glioblastoma

Giant Cell Glioblastoma

Monstrocellular Sarcoma

Glioblastoma

Glioblastoma Multiforme	Gbm
Adult Glioblastoma Multiforme	Grade Iv Adult Astrocytic Tumor
Primary Glioblastoma Multiforme	Spongioblastoma Multiforme
Adult Glioblastoma	Primary Glioblastoma

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