NSA2 - NSA2 ribosome biogenesis factor Gene

Homo sapiens

Also known as HCLG1; TINP1; CDK105; HCL-G1; HUSSY29; HUSSY-29

Gene ID: 10412 | Gene type: protein coding

About NSA2

Cytogenetic location: 5q13.3 Genomic coordinates (GRCh38): 5:74,767,249-74,780,113 (from NCBI)

This gene has 5 transcripts (splice variants) and 175 orthologues. Ubiquitous expression in ovary (RPKM 71.9), lymph node (RPKM 43.0) and 25 other tissues.

Summary

This gene encodes a nucleolar protein involved in cell cycle regulation and proliferation. This gene was identified based on sequence similarity to a highly conserved Saccharomyces cerevisiae gene encoding a pre-ribosomal protein, which is involved in large ribosomal subunit biogenesis. The encoded protein is found at elevated levels in diabetic nephropathy. Alternative splicing results in multiple transcript variants. Several related pseudogenes have been identified. [provided by RefSeq, Nov 2012]

NSA2 Products(3)

mRNA	Protein	Name
NM_001271665.2	NP_001258594.1	ribosome biogenesis protein NSA2 homolog isoform 2
NM_001364506.2	NP_001351435.1	ribosome biogenesis protein NSA2 homolog isoform 3
NM_014886.6	NP_055701.1	ribosome biogenesis protein NSA2 homolog isoform 1

NSA2 Protein Structure

Ribosomal_S8e

0
100
200
260 a.a.

Protein Preferred Names

Protein Names

ribosome biogenesis protein NSA2 homolog

NSA2, ribosome biogenesis homolog

Related Diseases

Diseases

Alias

Hairy Cell Leukemia

Hcl-V	Hairy Cell Leukemia Variant
Hairy Cell Leukaemia Variant	Hcl
Leukemic Reticuloendotheliosis	Leukemic Reticuloendotheliosis Variant
Prolymphocytic Variant Of Hcl	Prolymphocytic Variant Of Hairy Cell Leukemia
Leukemia Hairy Cell	Leukemia, Hairy Cell
Leukaemic Reticuloendotheliosis	Lre - [Leukemic Reticuloendotheliosis]
Hairy-Cell Leukaemia, Nos	Hcl - [Hairy Cell Leukaemia]
Hairy-Cell Leukaemia Without Mention Of Remission

Lateral Ventricle Meningioma

Meningioma Of The Lateral Ventricle

Louping Ill

Alopecia, Neurologic Defects, And Endocrinopathy Syndrome

Ane Syndrome	ANES
Alopecia-Progressive Neurological Defect-Endocrinopathy Syndrome	Alopecia-Progressive Neurological Defect-Endocrinopathy
Endocrine System Diseases

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09586	NSA2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	NSA2	RGD	RGD:621335
Mus musculus	NSA2	MGD	MGI:1913883
Macaca mulatta	NSA2	VGNC	VGNC:84455