2. Gene
  3. ENOX2 - ecto-NOX disulfide-thiol exchanger 2 Gene

ENOX2 - ecto-NOX disulfide-thiol exchanger 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as APK1; tNOX; COVA1

Gene ID: 10495 | Gene type: protein coding

About ENOX2

Cytogenetic location: Xq26.1 Genomic coordinates (GRCh38): X:130,622,325-130,903,209 (from NCBI)

This gene has 7 transcripts (splice variants), 228 orthologues and 1 paralogue. Ubiquitous expression in adrenal (RPKM 2.9), lymph node (RPKM 2.8) and 25 other tissues.

Summary

This gene is a tumor-specific member of the ECTO-NOX family of genes that encode cell surface NADH oxidases. The encoded protein has two enzymatic activities: catalysis of hydroquinone or NADH oxidation, and protein disulfide interchange. The protein also displays prion-like properties. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

ENOX2 Products(10)

mRNA Protein Name
NM_001281736.2 NP_001268665.1 ecto-NOX disulfide-thiol exchanger 2 isoform a
NM_001382516.1 NP_001369445.1 ecto-NOX disulfide-thiol exchanger 2 isoform b
NM_001382517.1 NP_001369446.1 ecto-NOX disulfide-thiol exchanger 2 isoform b
NM_001382518.1 NP_001369447.1 ecto-NOX disulfide-thiol exchanger 2 isoform c
NM_001382519.1 NP_001369448.1 ecto-NOX disulfide-thiol exchanger 2 isoform d
NM_001382520.1 NP_001369449.1 ecto-NOX disulfide-thiol exchanger 2 isoform d
NM_001382521.1 NP_001369450.1 ecto-NOX disulfide-thiol exchanger 2 isoform e
NM_001382522.1 NP_001369451.1 ecto-NOX disulfide-thiol exchanger 2 isoform e
NM_006375.4 NP_006366.2 ecto-NOX disulfide-thiol exchanger 2 isoform a
NM_182314.3 NP_872114.1 ecto-NOX disulfide-thiol exchanger 2 isoform b

ENOX2 Protein Structure

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (130 - 186)

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Protein Preferred Names Protein Names

ecto-NOX disulfide-thiol exchanger 2

APK1 antigen

Related Diseases

Diseases Alias
Suppressor Of Tumorigenicity 3

Cervical Carcinoma

ST3

Tumor-Suppressor Gene, Hela Cell Type

Tshl

Cervical Carcinoma, Tumor-Suppressor Gene Involved In

Ccts

Cervix Carcinoma
Variegate Porphyria

Porphyria Variegata

Protoporphyrinogen Oxidase Deficiency

VP

Ppox Deficiency

Porphyria, South African Type

Porphyria Variegata, Susceptibility To

Protocoproporphyria

Porphyria Variegate

Porphyria South African Type

Pv

Porphyria, Variegate

Vp - [Variegate Porphyria]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04385 ENOX2 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus ENOX2 VGNC VGNC:106725
Felis catus ENOX2 VGNC VGNC:61870
Rattus norvegicus ENOX2 RGD RGD:1563643
Macaca mulatta ENOX2 VGNC VGNC:72086
Canis familiaris ENOX2 VGNC VGNC:40372
Mus musculus ENOX2 MGD MGI:2384799