ENOX2 - ecto-NOX disulfide-thiol exchanger 2 Gene

Also Known as APK1; tNOX; COVA1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10495

About ENOX2

Cytogenetic location: Xq26.1 Genomic coordinates (GRCh38): X:130,622,325-130,903,209 (from NCBI)

This gene has 7 transcripts (splice variants), 228 orthologues and 1 paralogue. Ubiquitous expression in adrenal (RPKM 2.9), lymph node (RPKM 2.8) and 25 other tissues.

Summary

This gene is a tumor-specific member of the ECTO-NOX family of genes that encode cell surface NADH oxidases. The encoded protein has two enzymatic activities: catalysis of hydroquinone or NADH oxidation, and protein disulfide interchange. The protein also displays prion-like properties. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

ENOX2 Products (10)

mRNA Protein Name
NM_001281736.2 NP_001268665.1 ecto-NOX disulfide-thiol exchanger 2 isoform a
NM_001382516.1 NP_001369445.1 ecto-NOX disulfide-thiol exchanger 2 isoform b
NM_001382517.1 NP_001369446.1 ecto-NOX disulfide-thiol exchanger 2 isoform b
NM_001382518.1 NP_001369447.1 ecto-NOX disulfide-thiol exchanger 2 isoform c
NM_001382519.1 NP_001369448.1 ecto-NOX disulfide-thiol exchanger 2 isoform d
NM_001382520.1 NP_001369449.1 ecto-NOX disulfide-thiol exchanger 2 isoform d
NM_001382521.1 NP_001369450.1 ecto-NOX disulfide-thiol exchanger 2 isoform e
NM_001382522.1 NP_001369451.1 ecto-NOX disulfide-thiol exchanger 2 isoform e
NM_006375.4 NP_006366.2 ecto-NOX disulfide-thiol exchanger 2 isoform a
NM_182314.3 NP_872114.1 ecto-NOX disulfide-thiol exchanger 2 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
involved in electron transport chain IDA
IDA: Inferred from direct assay
11888291 GOA
involved in ultradian rhythm IDA
IDA: Inferred from direct assay
12356293 GOA
Cellular Component GO Annotation Evidence References Source
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
11488599 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ENOX2 Protein Structure

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (130 - 186)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 610 a.a.
Protein Preferred Names Protein Names

ecto-NOX disulfide-thiol exchanger 2

  • APK1 antigen

Related Diseases

Diseases Alias
Suppressor Of Tumorigenicity 3

  • Cervical Carcinoma

  • ST3

  • Tumor-Suppressor Gene, Hela Cell Type

  • Tshl

  • Cervical Carcinoma, Tumor-Suppressor Gene Involved In

  • Ccts

  • Cervix Carcinoma
Variegate Porphyria

  • Porphyria Variegata

  • Protoporphyrinogen Oxidase Deficiency

  • VP

  • Ppox Deficiency

  • Porphyria, South African Type

  • Porphyria Variegata, Susceptibility To

  • Protocoproporphyria

  • Porphyria Variegate

  • Porphyria South African Type

  • Pv

  • Porphyria, Variegate

  • Vp - [Variegate Porphyria]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04385 ENOX2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus ENOX2 VGNC VGNC:106725
Felis catus ENOX2 VGNC VGNC:61870
Rattus norvegicus ENOX2 RGD RGD:1563643
Macaca mulatta ENOX2 VGNC VGNC:72086
Canis familiaris ENOX2 VGNC VGNC:40372
Mus musculus ENOX2 MGD MGI:2384799
Others ENOX2 NCBI