SEMA4F - ssemaphorin 4F Gene

Also Known as S4F; SEMAM; SEMAW; M-SEMA; PRO2353; m-Sema-M

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10505

About SEMA4F

Cytogenetic location: 2p13.1 Genomic coordinates (GRCh38): 2:74,654,247-74,709,713 (from NCBI)

This gene has 10 transcripts (splice variants), 182 orthologues and 19 paralogues. Broad expression in brain (RPKM 2.1), testis (RPKM 1.1) and 22 other tissues.

Summary

This gene encodes a transmembrane class IV semaphorin family protein, which plays a role in neural development. This gene may be involved in neurogenesis in prostate Cancer, the development of neurofibromas, and breast Cancer tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

SEMA4F Products (3)

mRNA Protein Name
NM_001271661.2 NP_001258590.1 semaphorin-4F isoform 2 precursor
NM_001271662.2 NP_001258591.1 semaphorin-4F isoform 3 precursor
NM_004263.5 NP_004254.2 semaphorin-4F isoform 1 precursor

SEMA4F Protein Structure

Sema

Sema: Sema domain (65 - 493)

PSI

PSI: Plexin repeat (512 - 563)

  • 0
  • 200
  • 400
  • 600
  • 770 a.a.
Protein Preferred Names Protein Names

semaphorin-4F

  • sema domain immunoglobulin domain transmembrane domain (TM) and short cytoplasmic domain (semaphorin) 4F

Related Diseases

Diseases Alias
Dyslexia
Diffuse Glomerulonephritis

  • Glomerulonephritis Diffuse
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Kallmann Syndrome

  • Hypogonadism With Anosmia

  • Kallman'S Syndrome

  • Anosmic Hypogonadism

  • Anosmic Idiopathic Hypogonadotropic Hypogonadism

  • Hypogonadotropic Hypogonadism And Anosmia

  • Hypogonadotropic Hypogonadism-Anosmia Syndrome

  • Olfacto-Genital Pathological Sequence

  • Familial Hypogonadism With Anosmia

  • Kallman Syndrome

  • Dysplasia Olfactogenitalis Of De Morsier

  • Kallmann'S Syndrome

  • Congenital Hypogonadotropic Hypogonadism With Anosmia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12661 SEMA4F Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta SEMA4F VGNC VGNC:77167
Canis familiaris SEMA4F VGNC VGNC:45997
Bos taurus SEMA4F VGNC VGNC:34437
Mus musculus SEMA4F MGD MGI:1340055
Rattus norvegicus SEMA4F RGD RGD:3658