SEMA4B - semaphorin 4B Gene

Also Known as SemC; SEMAC

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10509

About SEMA4B

Cytogenetic location: 15q26.1 Genomic coordinates (GRCh38): 15:90,184,920-90,229,661 (from NCBI)

This gene has 20 transcripts (splice variants), 258 orthologues and 19 paralogues. Ubiquitous expression in esophagus (RPKM 24.0), skin (RPKM 20.0) and 25 other tissues.

Summary

Predicted to enable chemorepellent activity and semaphorin receptor binding activity. Predicted to be involved in several processes, including generation of neurons; neural crest cell migration; and semaphorin-plexin signaling pathway. Predicted to be located in plasma membrane. Predicted to be active in extracellular space. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

SEMA4B Products (8)

mRNA	Protein	Name
NM_001324029.3	NP_001310958.1	semaphorin-4B isoform 2
NM_001324030.3	NP_001310959.1	semaphorin-4B isoform 3
NM_001324031.4	NP_001310960.2	semaphorin-4B isoform 1 precursor
NM_001324032.3	NP_001310961.1	semaphorin-4B isoform 5 precursor
NM_001324034.3	NP_001310963.1	semaphorin-4B isoform 6 precursor
NM_001393916.1	NP_001380845.1	semaphorin-4B isoform 5 precursor
NM_020210.5	NP_064595.2	semaphorin-4B isoform 1 precursor
NM_198925.4	NP_945119.1	semaphorin-4B isoform 1 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	33845483	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SEMA4B Protein Structure

Sema

PSI

0
200
400
600
800
837 a.a.

Protein Preferred Names	Protein Names
semaphorin-4B	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B

SEMA4B Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	SEMA4B	Q9NPR2	ns7b_sars2	SARS-CoV-2	P0DTD8	Y2H Array	36217030

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SEMA4B Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71284	Semaphorin-4B/SEMA4B Protein, Human (HEK293, His)	Q9NPR2-1 (L44-E717)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Kallmann Syndrome	Hypogonadism With Anosmia Kallman'S Syndrome Anosmic Hypogonadism Anosmic Idiopathic Hypogonadotropic Hypogonadism Hypogonadotropic Hypogonadism And Anosmia Hypogonadotropic Hypogonadism-Anosmia Syndrome Olfacto-Genital Pathological Sequence Familial Hypogonadism With Anosmia Kallman Syndrome Dysplasia Olfactogenitalis Of De Morsier Kallmann'S Syndrome Congenital Hypogonadotropic Hypogonadism With Anosmia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12658	SEMA4B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18569	Sema4b Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25053	Sema4b Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SEMA4B	VGNC	VGNC:64993
Rattus norvegicus	SEMA4B	RGD	RGD:1307872
Macaca mulatta	SEMA4B	VGNC	VGNC:77165
Mus musculus	SEMA4B	MGD	MGI:107559
Canis familiaris	SEMA4B	VGNC	VGNC:45995
Bos taurus	SEMA4B	VGNC	VGNC:34434
Others	SEMA4B	NCBI