2. Gene
  3. SEMA4B - semaphorin 4B Gene

SEMA4B - semaphorin 4B Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as SemC; SEMAC

Gene ID: 10509 | Gene type: protein coding

About SEMA4B

Cytogenetic location: 15q26.1 Genomic coordinates (GRCh38): 15:90,184,920-90,229,661 (from NCBI)

This gene has 20 transcripts (splice variants), 258 orthologues and 19 paralogues. Ubiquitous expression in esophagus (RPKM 24.0), skin (RPKM 20.0) and 25 other tissues.

Summary

Predicted to enable chemorepellent activity and semaphorin receptor binding activity. Predicted to be involved in several processes, including generation of neurons; neural crest cell migration; and semaphorin-plexin signaling pathway. Predicted to be located in plasma membrane. Predicted to be active in extracellular space. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

SEMA4B Products(8)

mRNA Protein Name
NM_001324029.3 NP_001310958.1 semaphorin-4B isoform 2
NM_001324030.3 NP_001310959.1 semaphorin-4B isoform 3
NM_001324031.4 NP_001310960.2 semaphorin-4B isoform 1 precursor
NM_001324032.3 NP_001310961.1 semaphorin-4B isoform 5 precursor
NM_001324034.3 NP_001310963.1 semaphorin-4B isoform 6 precursor
NM_001393916.1 NP_001380845.1 semaphorin-4B isoform 5 precursor
NM_020210.5 NP_064595.2 semaphorin-4B isoform 1 precursor
NM_198925.4 NP_945119.1 semaphorin-4B isoform 1 precursor

SEMA4B Protein Structure

Sema

Sema: Sema domain (71 - 504)

PSI

PSI: Plexin repeat (525 - 566)

  • 0
  • 200
  • 400
  • 600
  • 837 a.a.
Protein Preferred Names Protein Names

semaphorin-4B

sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B

Recombinant SEMA4B Proteins

Cat. No. Product Name Accession Purity
HY-P71284 Semaphorin-4B/SEMA4B Protein, Human (HEK293, His) Q9NPR2 (L44-E717) ≥95%

Related Diseases

Diseases Alias
Kallmann Syndrome

Hypogonadism With Anosmia

Kallman'S Syndrome

Anosmic Hypogonadism

Anosmic Idiopathic Hypogonadotropic Hypogonadism

Hypogonadotropic Hypogonadism And Anosmia

Hypogonadotropic Hypogonadism-Anosmia Syndrome

Olfacto-Genital Pathological Sequence

Familial Hypogonadism With Anosmia

Kallman Syndrome

Dysplasia Olfactogenitalis Of De Morsier

Kallmann'S Syndrome

Congenital Hypogonadotropic Hypogonadism With Anosmia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12658 SEMA4B Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus SEMA4B VGNC VGNC:64993
Rattus norvegicus SEMA4B RGD RGD:1307872
Macaca mulatta SEMA4B VGNC VGNC:77165
Mus musculus SEMA4B MGD MGI:107559
Canis familiaris SEMA4B VGNC VGNC:45995
Bos taurus SEMA4B VGNC VGNC:34434
Others SEMA4B NCBI