Ano6 - anoctamin 6 Gene

Also Known as Tmem16f; 2900059G15Rik; F730003B03Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 105722

Summary

Enables gated channel activity; phospholipid scramblase activity; and protein homodimerization activity. Involved in several processes, including bleb assembly; inorganic ion transmembrane transport; and positive regulation of transport. Acts upstream of or within several processes, including bone mineralization involved in bone maturation; calcium activated phospholipid scrambling; and dendritic cell chemotaxis. Is integral component of plasma membrane. Is expressed in several structures, including alimentary system; nervous system; respiratory system; sensory organ; and viscerocranium. Human ortholog(s) of this gene implicated in Scott syndrome; ankylosing spondylitis; and inflammatory bowel disease. Orthologous to human ANO6 (anoctamin 6). [provided by Alliance of Genome Resources, Apr 2022]

Ano6 Products (2)

mRNA Protein Name
NM_001253813.1 NP_001240742.1 anoctamin-6 isoform 1
NM_175344.4 NP_780553.2 anoctamin-6 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables calcium-activated cation channel activity IDA
IDA: Inferred from direct assay
23021219 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
23576756 MGI
NOT enables intracellularly calcium-gated chloride channel activity IDA
IDA: Inferred from direct assay
22075693 MGI
enables intracellularly calcium-gated chloride channel activity IDA
IDA: Inferred from direct assay
20056604 MGI
enables intracellularly calcium-gated chloride channel activity IMP
IMP: Inferred from mutant phenotype
23159814 MGI
enables phospholipid scramblase activity IDA
IDA: Inferred from direct assay
23532839 MGI
enables phospholipid scramblase activity IMP
IMP: Inferred from mutant phenotype
23532839 MGI
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
30785399 MGI
enables voltage-gated monoatomic ion channel activity IDA
IDA: Inferred from direct assay
23021219 MGI
Biological Process GO Annotation Evidence Verweise Source
involved in bleb assembly IMP
IMP: Inferred from mutant phenotype
25651887 MGI
involved in blood coagulation IMP
IMP: Inferred from mutant phenotype
23021219 MGI
acts upstream of or within bone mineralization involved in bone maturation IMP
IMP: Inferred from mutant phenotype
22936354 MGI
acts upstream of or within calcium activated galactosylceramide scrambling IDA
IDA: Inferred from direct assay
23532839 MGI
acts upstream of or within calcium activated phosphatidylcholine scrambling IDA
IDA: Inferred from direct assay
23532839 MGI
acts upstream of or within calcium activated phosphatidylserine scrambling IDA
IDA: Inferred from direct assay
23532839 MGI
acts upstream of or within calcium activated phospholipid scrambling IMP
IMP: Inferred from mutant phenotype
22936354 MGI
involved in calcium ion transmembrane transport IGI
IGI: Inferred from genetic interaction
25589784 MGI
involved in chloride transmembrane transport IDA
IDA: Inferred from direct assay
30785399 MGI
involved in chloride transmembrane transport IMP
IMP: Inferred from mutant phenotype
25589784 MGI
acts upstream of or within chloride transport IDA
IDA: Inferred from direct assay
20056604 MGI
acts upstream of or within chloride transport IMP
IMP: Inferred from mutant phenotype
23159814 MGI
acts upstream of or within dendritic cell chemotaxis IMP
IMP: Inferred from mutant phenotype
23159814 MGI
acts upstream of or within establishment of localization in cell IDA
IDA: Inferred from direct assay
23532839 MGI
acts upstream of or within establishment of localization in cell IMP
IMP: Inferred from mutant phenotype
22936354 MGI
involved in negative regulation of cell volume IMP
IMP: Inferred from mutant phenotype
25651887 MGI
NOT acts upstream of or within phosphatidylserine exposure on apoptotic cell surface IMP
IMP: Inferred from mutant phenotype
22936354 MGI
involved in phospholipid translocation IDA
IDA: Inferred from direct assay
30785399 MGI
involved in plasma membrane phospholipid scrambling IMP
IMP: Inferred from mutant phenotype
23021219 MGI
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
25651887 MGI
involved in positive regulation of bone mineralization IMP
IMP: Inferred from mutant phenotype
25589784 MGI
involved in positive regulation of monoatomic ion transmembrane transport IMP
IMP: Inferred from mutant phenotype
25651887 MGI
involved in positive regulation of monocyte chemotaxis IMP
IMP: Inferred from mutant phenotype
25651887 MGI
involved in positive regulation of phagocytosis, engulfment IMP
IMP: Inferred from mutant phenotype
25651887 MGI
involved in purinergic nucleotide receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
25651887 MGI
involved in regulation of postsynaptic membrane potential IDA
IDA: Inferred from direct assay
32101737 MGI
involved in regulation of postsynaptic membrane potential IMP
IMP: Inferred from mutant phenotype
32101737 MGI
Cellular Component GO Annotation Evidence Verweise Source
is active in cholinergic synapse IDA
IDA: Inferred from direct assay
32101737 MGI
is active in cholinergic synapse IMP
IMP: Inferred from mutant phenotype
32101737 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
30785399 MGI
is active in synaptic membrane IDA
IDA: Inferred from direct assay
32101737 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

anoctamin-6

  • SCAN channel

  • small-conductance calcium-activated nonselective cation channel

  • transmembrane protein 16F

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-164139 Antiviral agent 57 Inhibitor 98.10% Unkown
HY-RS00746 ANO6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20248 Ano6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26756 Ano6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ano6 NCBI NCBI:196527