Ano6 - anoctamin 6 Gene

Mus musculus

Also known as Tmem16f; 2900059G15Rik; F730003B03Rik

Gene ID: 105722 | Gene type: protein coding

About Ano6

Summary

Enables gated channel activity; phospholipid scramblase activity; and protein homodimerization activity. Involved in several processes, including bleb assembly; inorganic ion transmembrane transport; and positive regulation of transport. Acts upstream of or within several processes, including bone mineralization involved in bone maturation; calcium activated phospholipid scrambling; and dendritic cell chemotaxis. Is integral component of plasma membrane. Is expressed in several structures, including alimentary system; nervous system; respiratory system; sensory organ; and viscerocranium. Human ortholog(s) of this gene implicated in Scott syndrome; ankylosing spondylitis; and inflammatory bowel disease. Orthologous to human ANO6 (anoctamin 6). [provided by Alliance of Genome Resources, Apr 2022]

Ano6 Products(2)

mRNA	Protein	Name
NM_001253813.1	NP_001240742.1	anoctamin-6 isoform 1
NM_175344.4	NP_780553.2	anoctamin-6 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium-activated cation channel activity	IDA IDA: Inferred from direct assay	23021219	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	23576756	MGI
NOT enables intracellularly calcium-gated chloride channel activity	IDA IDA: Inferred from direct assay	22075693	MGI
enables intracellularly calcium-gated chloride channel activity	IDA IDA: Inferred from direct assay	20056604	MGI
enables intracellularly calcium-gated chloride channel activity	IMP IMP: Inferred from mutant phenotype	23159814	MGI
enables phospholipid scramblase activity	IDA IDA: Inferred from direct assay	23532839	MGI
enables phospholipid scramblase activity	IMP IMP: Inferred from mutant phenotype	23532839	MGI
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	30785399	MGI
enables voltage-gated monoatomic ion channel activity	IDA IDA: Inferred from direct assay	23021219	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in bleb assembly	IMP IMP: Inferred from mutant phenotype	25651887	MGI
involved in blood coagulation	IMP IMP: Inferred from mutant phenotype	23021219	MGI
acts upstream of or within bone mineralization involved in bone maturation	IMP IMP: Inferred from mutant phenotype	22936354	MGI
acts upstream of or within calcium activated galactosylceramide scrambling	IDA IDA: Inferred from direct assay	23532839	MGI
acts upstream of or within calcium activated phosphatidylcholine scrambling	IDA IDA: Inferred from direct assay	23532839	MGI
acts upstream of or within calcium activated phosphatidylserine scrambling	IDA IDA: Inferred from direct assay	23532839	MGI
acts upstream of or within calcium activated phospholipid scrambling	IMP IMP: Inferred from mutant phenotype	22936354	MGI
involved in calcium ion transmembrane transport	IGI IGI: Inferred from genetic interaction	25589784	MGI
involved in chloride transmembrane transport	IDA IDA: Inferred from direct assay	30785399	MGI
involved in chloride transmembrane transport	IMP IMP: Inferred from mutant phenotype	25589784	MGI
acts upstream of or within chloride transport	IDA IDA: Inferred from direct assay	20056604	MGI
acts upstream of or within chloride transport	IMP IMP: Inferred from mutant phenotype	23159814	MGI
acts upstream of or within dendritic cell chemotaxis	IMP IMP: Inferred from mutant phenotype	23159814	MGI
acts upstream of or within establishment of localization in cell	IDA IDA: Inferred from direct assay	23532839	MGI
acts upstream of or within establishment of localization in cell	IMP IMP: Inferred from mutant phenotype	22936354	MGI
involved in negative regulation of cell volume	IMP IMP: Inferred from mutant phenotype	25651887	MGI
NOT acts upstream of or within phosphatidylserine exposure on apoptotic cell surface	IMP IMP: Inferred from mutant phenotype	22936354	MGI
involved in phospholipid translocation	IDA IDA: Inferred from direct assay	30785399	MGI
involved in plasma membrane phospholipid scrambling	IMP IMP: Inferred from mutant phenotype	23021219	MGI
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	25651887	MGI
involved in positive regulation of bone mineralization	IMP IMP: Inferred from mutant phenotype	25589784	MGI
involved in positive regulation of monoatomic ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	25651887	MGI
involved in positive regulation of monocyte chemotaxis	IMP IMP: Inferred from mutant phenotype	25651887	MGI
involved in positive regulation of phagocytosis, engulfment	IMP IMP: Inferred from mutant phenotype	25651887	MGI
involved in purinergic nucleotide receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	25651887	MGI
involved in regulation of postsynaptic membrane potential	IDA IDA: Inferred from direct assay	32101737	MGI
involved in regulation of postsynaptic membrane potential	IMP IMP: Inferred from mutant phenotype	32101737	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in cholinergic synapse	IDA IDA: Inferred from direct assay	32101737	MGI
is active in cholinergic synapse	IMP IMP: Inferred from mutant phenotype	32101737	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	30785399	MGI
is active in synaptic membrane	IDA IDA: Inferred from direct assay	32101737	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

anoctamin-6

SCAN channel	small-conductance calcium-activated nonselective cation channel
transmembrane protein 16F

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-164139	Antiviral agent 57	Inhibitor	98.10%	Unkown
HY-RS00746	ANO6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20248	Ano6 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26756	Ano6 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ano6	NCBI	NCBI:196527

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