IVNS1ABP - influenza virus NS1A binding protein Gene

Also Known as ND1; ARA3; NS-1; IMD70; NS1BP; FLARA3; KLHL39; NS1-BP; HSPC068

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10625

About IVNS1ABP

Cytogenetic location: 1q25.3 Genomic coordinates (GRCh38): 1:185,296,388-185,317,243 (from NCBI)

This gene has 9 transcripts (splice variants), 223 orthologues, 54 paralogues and is associated with 1 phenotype. Ubiquitous expression in bone marrow (RPKM 56.1), kidney (RPKM 31.5) and 24 other tissues.

Summary

Involved in RNA splicing; negative regulation of protein ubiquitination; and response to virus. Located in cytosol. Implicated in immunodeficiency 70. [provided by Alliance of Genome Resources, Apr 2022]

IVNS1ABP Products (1)

mRNA Protein Name
NM_006469.5 NP_006460.2 influenza virus NS1A-binding protein

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
23825951 GOA
Biological Process GO Annotation Evidence References Source
involved in RNA splicing IMP
IMP: Inferred from mutant phenotype
23825951 GOA
involved in negative regulation of protein ubiquitination IMP
IMP: Inferred from mutant phenotype
25619834 GOA
involved in response to virus IMP
IMP: Inferred from mutant phenotype
23825951 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IVNS1ABP Protein Structure

BTB

BTB: BTB/POZ domain (22 - 126)

BACK

BACK: BTB And C-terminal Kelch (134 - 221)

Kelch_1

Kelch_1: Kelch motif (357 - 402)

Kelch_1

Kelch_1: Kelch motif (404 - 449)

Kelch_1

Kelch_1: Kelch motif (453 - 499)

Kelch_1

Kelch_1: Kelch motif (501 - 546)

Kelch_1

Kelch_1: Kelch motif (548 - 592)

Kelch_1

Kelch_1: Kelch motif (595 - 635)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 600
  • 642 a.a.
Protein Preferred Names Protein Names

influenza virus NS1A-binding protein

  • NCX downstream gene 1

Related Diseases

Diseases Alias
Immunodeficiency 70

  • IMD70
Influenza

  • Flu

  • Influenza With Non-Respiratory Manifestation

  • Influenza With Other Manifestations

  • Influenza, Human

  • Influenza, Susceptibility To

  • Seasonal Influenza, Virus Identified
Leber Hereditary Optic Neuropathy, Modifier Of

  • Leber Optic Atrophy

  • Leber Hereditary Optic Neuropathy

  • LHON

  • Leber'S Hereditary Optic Neuropathy

  • Leber Optic Atrophy, Susceptibility To

  • Leber'S Optic Atrophy

  • LOAM

  • Loas

  • Leber'S Disease

  • Leber'S Optic Neuropathy

  • Optic Atrophy, Hereditary, Leber

  • Lhon, Modifier Of

  • Optic Atrophy, Leber Type

  • Hereditary Optic Neuroretinopathy

  • Leber Hereditary Optic Atrophy

  • Loa

  • Optic Atrophy Leber Type

  • Leber Hereditary Optic Neuropathy, Modifier

  • Leber Hereditary Optic Neuropathy Susceptibility

  • Modifier Of Leber Hereditary Optic Neuropathy

  • Lebers Hereditary Optic Neuropathy

  • Leber Congenital Amaurosis
Tick-Borne Encephalitis

  • Siberian Tick-Borne Encephalitis

  • Encephalitis, Tick-Borne

  • Central European Encephalitis

  • Far Eastern Tbe

  • Russian Spring-Summer Encephalitis

  • Taiga Encephalitis

  • West-Siberian Encephalitis

  • Western European Tick-Borne Encephalitis

  • Tbe

  • Encephalitis Tick-Borne

  • Encephalitis, Central European

  • Encephalitis, Far Eastern Russian
Japanese Encephalitis

  • Japanese B Encephalitis

  • Je

  • Encephalitis Japanese

  • Encephalitis, Japanese

  • Russian Autumnal Encephalitis

  • Je - [Japanese Encephalitis]

  • Japanese Encephalitis Virus Disease

  • Jbe - [Japanese B Encephalitis}

  • B Type Encephalitis
Dengue Disease

  • Dengue Fever

  • Dengue

  • Df

  • Dengue Shock Syndrome

  • Dengue Virus Infection

  • Breakbone Fever

  • Classic Dengue

  • Classical Dengue

  • Dengue Hemorrhagic Fever

  • Hemorrhagic Dengue

  • Philippine Hemorrhagic Fever

  • Singapore Hemorrhagic Fever

  • Thai Hemorrhagic Fever

  • Severe Dengue

  • Dengue Fever Without Warning Signs

  • Dengue Haemorrhagic Fever Grade 1

  • Dengue Haemorrhagic Fever Without Warning Signs

  • Bangkok Haemorrhagic Fever

  • Singapore Haemorrhagic Fever

  • Thailand Haemorrhagic Fever

  • Southeast Asia Haemorrhagic Fever

  • Dhf -[Dengue Haemorrhagic Fever]

  • Dengue Fever With Warning Signs

  • Dengue Haemorrhagic Fever With Warning Signs

  • Dengue Haemorrhagic Fever Grade 2

  • Philippine Haemorrhagic Fever
Newcastle Disease

  • Newcastle'S Disease

  • Pseudo-Fowlpest
Dengue Hemorrhagic Fever

  • Severe Dengue

  • Dengue Haemorrhagic Fever

  • Dhf

  • Severe Dengue Haemorrhagic Fever

  • Severe Dengue Fever

  • Dengue Shock Syndrome
Retinal Vasculitis
Dengue Shock Syndrome

  • Dss
Shrimp Allergy
Venezuelan Hemorrhagic Fever

  • Guanarito Hemorrhagic Fever

  • Vehf - [Venezuelan Haemorrhagic Fever]
Viral Infectious Disease

  • Viral Disease

  • Arbovirus Infections

  • Virus Infection

  • Virus Diseases

  • Viral Infection

  • Viral Infections

  • Virus Infections
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07001 IVNS1ABP Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus IVNS1ABP RGD RGD:1306290
Macaca mulatta IVNS1ABP VGNC VGNC:99985
Mus musculus IVNS1ABP MGD MGI:2152389
Others IVNS1ABP NCBI