CELF2 - CUGBP Elav-like family member 2 Gene

Also Known as ETR3; DEE97; ETR-3; NAPOR; CELF-2; CUGBP2; BRUNOL3; CUG-BP2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10659

About CELF2

Cytogenetic location: 10p14 Genomic coordinates (GRCh38): 10:10,462,550-11,336,675 (from NCBI)

This gene has 17 transcripts (splice variants), 292 orthologues, 6 paralogues and is associated with 3 phenotypes. Broad expression in brain (RPKM 19.5), bone marrow (RPKM 16.3) and 21 other tissues.

Summary

Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

CELF2 Products (41)

mRNA Protein Name
NM_001025076.2 NP_001020247.1 CUGBP Elav-like family member 2 isoform 1
NM_001025077.3 NP_001020248.1 CUGBP Elav-like family member 2 isoform 3
NM_001083591.1 NP_001077060.1 CUGBP Elav-like family member 2 isoform 4
NM_001326317.2 NP_001313246.1 CUGBP Elav-like family member 2 isoform 5
NM_001326318.2 NP_001313247.1 CUGBP Elav-like family member 2 isoform 1
NM_001326319.2 NP_001313248.1 CUGBP Elav-like family member 2 isoform 23
NM_001326320.2 NP_001313249.1 CUGBP Elav-like family member 2 isoform 1
NM_001326321.2 NP_001313250.1 CUGBP Elav-like family member 2 isoform 6
NM_001326323.2 NP_001313252.1 CUGBP Elav-like family member 2 isoform 7
NM_001326324.2 NP_001313253.1 CUGBP Elav-like family member 2 isoform 1
NM_001326325.2 NP_001313254.1 CUGBP Elav-like family member 2 isoform 8
NM_001326326.2 NP_001313255.1 CUGBP Elav-like family member 2 isoform 9
NM_001326327.2 NP_001313256.1 CUGBP Elav-like family member 2 isoform 10
NM_001326328.2 NP_001313257.1 CUGBP Elav-like family member 2 isoform 1
NM_001326329.2 NP_001313258.1 CUGBP Elav-like family member 2 isoform 5
NM_001326330.2 NP_001313259.1 CUGBP Elav-like family member 2 isoform 1
NM_001326331.2 NP_001313260.1 CUGBP Elav-like family member 2 isoform 11
NM_001326332.2 NP_001313261.1 CUGBP Elav-like family member 2 isoform 3
NM_001326333.2 NP_001313262.1 CUGBP Elav-like family member 2 isoform 12
NM_001326334.2 NP_001313263.1 CUGBP Elav-like family member 2 isoform 1
NM_001326335.2 NP_001313264.1 CUGBP Elav-like family member 2 isoform 13
NM_001326336.2 NP_001313265.1 CUGBP Elav-like family member 2 isoform 14
NM_001326337.2 NP_001313266.1 CUGBP Elav-like family member 2 isoform 15
NM_001326338.2 NP_001313267.1 CUGBP Elav-like family member 2 isoform 16
NM_001326339.2 NP_001313268.1 CUGBP Elav-like family member 2 isoform 17
NM_001326340.2 NP_001313269.1 CUGBP Elav-like family member 2 isoform 18
NM_001326341.2 NP_001313270.1 CUGBP Elav-like family member 2 isoform 19
NM_001326342.2 NP_001313271.1 CUGBP Elav-like family member 2 isoform 2
NM_001326343.2 NP_001313272.1 CUGBP Elav-like family member 2 isoform 22
NM_001326344.2 NP_001313273.1 CUGBP Elav-like family member 2 isoform 5
NM_001326345.2 NP_001313274.1 CUGBP Elav-like family member 2 isoform 1
NM_001326346.2 NP_001313275.1 CUGBP Elav-like family member 2 isoform 20
NM_001326347.1 NP_001313276.1 CUGBP Elav-like family member 2 isoform 21
NM_001326348.2 NP_001313277.1 CUGBP Elav-like family member 2 isoform 5
NM_001326349.2 NP_001313278.1 CUGBP Elav-like family member 2 isoform 1
NM_001394502.1 NP_001381431.1 CUGBP Elav-like family member 2 isoform 11
NM_001394513.1 NP_001381442.1 CUGBP Elav-like family member 2 isoform 19
NM_001394517.1 NP_001381446.1 CUGBP Elav-like family member 2 isoform 5
NM_001394518.1 NP_001381447.1 CUGBP Elav-like family member 2 isoform 24
NM_001394519.1 NP_001381448.1 CUGBP Elav-like family member 2 isoform 24
NM_006561.4 NP_006552.3 CUGBP Elav-like family member 2 isoform 2

CELF2 Protein Structure

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (43 - 111)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (134 - 198)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (425 - 494)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 508 a.a.
Protein Preferred Names Protein Names

CUGBP Elav-like family member 2

  • CUG triplet repeat RNA-binding protein 2

CELF2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82735 CELF2 Antibody (YA2480) WB, IHC-F, IHC-P, ICC/IF, IP Human, Mouse, Rat
HY-P82735A CELF2 Antibody (YA2480)(PBS only) WB, IHC-F, IHC-P, ICC/IF, IP Human, Mouse, Rat

Related Diseases

Diseases Alias
Developmental And Epileptic Encephalopathy 97

  • DEE97

  • Encephalopathy, Developmental And Epileptic, Type 97
Non-Specific Early-Onset Epileptic Encephalopathy

  • Undetermined Early-Onset Epileptic Encephalopathy

  • Non-Specific Eoee

  • Undetermined Eoee
Myotonic Dystrophy 1

  • Myotonic Dystrophy

  • Dystrophia Myotonica

  • Steinert Disease

  • Myotonic Dystrophy Type 1

  • Myotonia Atrophica

  • DM1

  • Congenital Myotonic Dystrophy

  • Myotonia Dystrophica

  • Steinert Myotonic Dystrophy

  • Dystrophia Myotonica 1

  • Dm

  • Steinert'S Disease

  • Steinert Myotonic Dystrophy Syndrome

  • Myotonic Dystrophy Of Steinert

  • Dystrophia Myotonica Type 1

  • Myotonic Dystrophy Congenital

  • Dystrophy, Myotonic, Type 1

  • Dm - [Dystrophia Myotonica]

  • Myotonic Muscular Dystrophy
Developmental And Epileptic Encephalopathy

  • Encephalopathy, Developmental And Epileptic
Neuroblastoma

  • Nb

  • Neuroblastoma, Susceptibility To

  • Neuroblastomas

  • Central Neuroblastoma
Myotonic Disease

  • Myotonic Disorders

  • Myotonic Syndrome

  • Symptomatic Myotonia
Spinal And Bulbar Muscular Atrophy, X-Linked 1

  • Kennedy Disease

  • Sbma

  • Spinal And Bulbar Muscular Atrophy

  • Kennedy'S Disease

  • X-Linked Spinal And Bulbar Muscular Atrophy

  • SMAX1

  • Kd

  • Kennedy Spinal And Bulbar Muscular Atrophy

  • Spinobulbar Muscular Atrophy

  • Bulbospinal Muscular Atrophy, X-Linked

  • Bulbospinal Neuronopathy, X-Linked Recessive

  • Xbsn

  • Spinal And Bulbar Muscular Atrophy Of Kennedy

  • Bulbospinal Muscular Atrophy

  • X-Linked Bulbospinal Amyotrophy

  • Bulbo-Spinal Atrophy, X-Linked

  • Spinal Bulbar Muscular Atrophy

  • X-Linked Bulbo-Spinal Atrophy

  • X-Linked Spinal Bulbar Muscular Atrophy

  • X-Linked Bsma

  • X-Linked Bulbospinal Muscular Atrophy

  • Spinal And Bulbar Muscular Atrophy X-Linked 1

  • Bulbospinal Muscular Atrophy X-Linked

  • Bulbospinal Neuronopathy X-Linked Recessive

  • Kennedy Disease)

  • Kennedy Syndrome

  • Atrophy, Muscular, Spinal And Bulbar, Kennedy Type

  • Atrophy, Muscular, Spinobulbar

  • Bulbospinal Neuronopathy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02460 CELF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22430 Celf2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28953 Celf2 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CELF2 RGD RGD:68347
Felis catus CELF2 VGNC VGNC:60745
Canis familiaris CELF2 VGNC VGNC:39094
Mus musculus CELF2 MGD MGI:1338822
Macaca mulatta CELF2 VGNC VGNC:106020
Others CELF2 NCBI