2. Gene
  3. CELF2 - CUGBP Elav-like family member 2 Gene

CELF2 - CUGBP Elav-like family member 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ETR3; DEE97; ETR-3; NAPOR; CELF-2; CUGBP2; BRUNOL3; CUG-BP2

Gene ID: 10659 | Gene type: protein coding

About CELF2

Cytogenetic location: 10p14 Genomic coordinates (GRCh38): 10:10,462,550-11,336,675 (from NCBI)

This gene has 17 transcripts (splice variants), 292 orthologues, 6 paralogues and is associated with 3 phenotypes. Broad expression in brain (RPKM 19.5), bone marrow (RPKM 16.3) and 21 other tissues.

Summary

Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

CELF2 Products(41)

mRNA Protein Name
NM_001025076.2 NP_001020247.1 CUGBP Elav-like family member 2 isoform 1
NM_001025077.3 NP_001020248.1 CUGBP Elav-like family member 2 isoform 3
NM_001083591.1 NP_001077060.1 CUGBP Elav-like family member 2 isoform 4
NM_001326317.2 NP_001313246.1 CUGBP Elav-like family member 2 isoform 5
NM_001326318.2 NP_001313247.1 CUGBP Elav-like family member 2 isoform 1
NM_001326319.2 NP_001313248.1 CUGBP Elav-like family member 2 isoform 23
NM_001326320.2 NP_001313249.1 CUGBP Elav-like family member 2 isoform 1
NM_001326321.2 NP_001313250.1 CUGBP Elav-like family member 2 isoform 6
NM_001326323.2 NP_001313252.1 CUGBP Elav-like family member 2 isoform 7
NM_001326324.2 NP_001313253.1 CUGBP Elav-like family member 2 isoform 1
NM_001326325.2 NP_001313254.1 CUGBP Elav-like family member 2 isoform 8
NM_001326326.2 NP_001313255.1 CUGBP Elav-like family member 2 isoform 9
NM_001326327.2 NP_001313256.1 CUGBP Elav-like family member 2 isoform 10
NM_001326328.2 NP_001313257.1 CUGBP Elav-like family member 2 isoform 1
NM_001326329.2 NP_001313258.1 CUGBP Elav-like family member 2 isoform 5
NM_001326330.2 NP_001313259.1 CUGBP Elav-like family member 2 isoform 1
NM_001326331.2 NP_001313260.1 CUGBP Elav-like family member 2 isoform 11
NM_001326332.2 NP_001313261.1 CUGBP Elav-like family member 2 isoform 3
NM_001326333.2 NP_001313262.1 CUGBP Elav-like family member 2 isoform 12
NM_001326334.2 NP_001313263.1 CUGBP Elav-like family member 2 isoform 1
NM_001326335.2 NP_001313264.1 CUGBP Elav-like family member 2 isoform 13
NM_001326336.2 NP_001313265.1 CUGBP Elav-like family member 2 isoform 14
NM_001326337.2 NP_001313266.1 CUGBP Elav-like family member 2 isoform 15
NM_001326338.2 NP_001313267.1 CUGBP Elav-like family member 2 isoform 16
NM_001326339.2 NP_001313268.1 CUGBP Elav-like family member 2 isoform 17
NM_001326340.2 NP_001313269.1 CUGBP Elav-like family member 2 isoform 18
NM_001326341.2 NP_001313270.1 CUGBP Elav-like family member 2 isoform 19
NM_001326342.2 NP_001313271.1 CUGBP Elav-like family member 2 isoform 2
NM_001326343.2 NP_001313272.1 CUGBP Elav-like family member 2 isoform 22
NM_001326344.2 NP_001313273.1 CUGBP Elav-like family member 2 isoform 5
NM_001326345.2 NP_001313274.1 CUGBP Elav-like family member 2 isoform 1
NM_001326346.2 NP_001313275.1 CUGBP Elav-like family member 2 isoform 20
NM_001326347.1 NP_001313276.1 CUGBP Elav-like family member 2 isoform 21
NM_001326348.2 NP_001313277.1 CUGBP Elav-like family member 2 isoform 5
NM_001326349.2 NP_001313278.1 CUGBP Elav-like family member 2 isoform 1
NM_001394502.1 NP_001381431.1 CUGBP Elav-like family member 2 isoform 11
NM_001394513.1 NP_001381442.1 CUGBP Elav-like family member 2 isoform 19
NM_001394517.1 NP_001381446.1 CUGBP Elav-like family member 2 isoform 5
NM_001394518.1 NP_001381447.1 CUGBP Elav-like family member 2 isoform 24
NM_001394519.1 NP_001381448.1 CUGBP Elav-like family member 2 isoform 24
NM_006561.4 NP_006552.3 CUGBP Elav-like family member 2 isoform 2

CELF2 Protein Structure

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (43 - 111)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (134 - 198)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (425 - 494)

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  • 508 a.a.
Protein Preferred Names Protein Names

CUGBP Elav-like family member 2

CUG triplet repeat RNA-binding protein 2

Related Diseases

Diseases Alias
Developmental And Epileptic Encephalopathy 97

DEE97

Encephalopathy, Developmental And Epileptic, Type 97
Non-Specific Early-Onset Epileptic Encephalopathy

Undetermined Early-Onset Epileptic Encephalopathy

Non-Specific Eoee

Undetermined Eoee
Myotonic Dystrophy 1

Myotonic Dystrophy

Dystrophia Myotonica

Steinert Disease

Myotonic Dystrophy Type 1

Myotonia Atrophica

DM1

Congenital Myotonic Dystrophy

Myotonia Dystrophica

Steinert Myotonic Dystrophy

Dystrophia Myotonica 1

Dm

Steinert'S Disease

Steinert Myotonic Dystrophy Syndrome

Myotonic Dystrophy Of Steinert

Dystrophia Myotonica Type 1

Myotonic Dystrophy Congenital

Dystrophy, Myotonic, Type 1

Dm - [Dystrophia Myotonica]

Myotonic Muscular Dystrophy
Developmental And Epileptic Encephalopathy

Encephalopathy, Developmental And Epileptic
Neuroblastoma

Nb

Neuroblastoma, Susceptibility To

Neuroblastomas

Central Neuroblastoma
Myotonic Disease

Myotonic Disorders

Myotonic Syndrome

Symptomatic Myotonia
Spinal And Bulbar Muscular Atrophy, X-Linked 1

Kennedy Disease

Sbma

Spinal And Bulbar Muscular Atrophy

Kennedy'S Disease

X-Linked Spinal And Bulbar Muscular Atrophy

SMAX1

Kd

Kennedy Spinal And Bulbar Muscular Atrophy

Spinobulbar Muscular Atrophy

Bulbospinal Muscular Atrophy, X-Linked

Bulbospinal Neuronopathy, X-Linked Recessive

Xbsn

Spinal And Bulbar Muscular Atrophy Of Kennedy

Bulbospinal Muscular Atrophy

X-Linked Bulbospinal Amyotrophy

Bulbo-Spinal Atrophy, X-Linked

Spinal Bulbar Muscular Atrophy

X-Linked Bulbo-Spinal Atrophy

X-Linked Spinal Bulbar Muscular Atrophy

X-Linked Bsma

X-Linked Bulbospinal Muscular Atrophy

Spinal And Bulbar Muscular Atrophy X-Linked 1

Bulbospinal Muscular Atrophy X-Linked

Bulbospinal Neuronopathy X-Linked Recessive

Kennedy Disease)

Kennedy Syndrome

Atrophy, Muscular, Spinal And Bulbar, Kennedy Type

Atrophy, Muscular, Spinobulbar

Bulbospinal Neuronopathy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02460 CELF2 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CELF2 RGD RGD:68347
Felis catus CELF2 VGNC VGNC:60745
Canis familiaris CELF2 VGNC VGNC:39094
Mus musculus CELF2 MGD MGI:1338822
Macaca mulatta CELF2 VGNC VGNC:106020