DHRS4 - dehydrogenase/reductase 4 Gene

Also Known as CR; NRDR; PHCR; PSCD; SDR-SRL; SDR25C1; SDR25C2; SCAD-SRL

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10901

About DHRS4

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:23,953,770-23,969,279 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 350 orthologues and 13 paralogues. Broad expression in kidney (RPKM 98.6), small intestine (RPKM 30.5) and 22 other tissues.

Summary

Enables identical protein binding activity; oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; and oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Involved in several processes, including cellular ketone metabolic process; positive regulation of Reactive Oxygen Species metabolic process; and steroid metabolic process. Located in nucleus and peroxisomal membrane. [provided by Alliance of Genome Resources, Apr 2022]

DHRS4 Products (7)

mRNA	Protein	Name
NM_001282987.2	NP_001269916.1	dehydrogenase/reductase SDR family member 4 isoform 2
NM_001282988.2	NP_001269917.1	dehydrogenase/reductase SDR family member 4 isoform 3
NM_001282989.2	NP_001269918.1	dehydrogenase/reductase SDR family member 4 isoform 4
NM_001282990.2	NP_001269919.1	dehydrogenase/reductase SDR family member 4 isoform 5
NM_001282991.2	NP_001269920.1	dehydrogenase/reductase SDR family member 4 isoform 6
NM_001411004.1	NP_001397933.1	dehydrogenase/reductase SDR family member 4 isoform 7
NM_021004.4	NP_066284.2	dehydrogenase/reductase SDR family member 4 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables 3-keto sterol reductase activity	IDA IDA: Inferred from direct assay	18571493	GOA
enables alcohol dehydrogenase [NAD(P)+] activity	IDA IDA: Inferred from direct assay	18571493	GOA
enables carbonyl reductase (NADPH) activity	IDA IDA: Inferred from direct assay	18571493	GOA
enables identical protein binding	IDA IDA: Inferred from direct assay	18571493	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	18571493	GOA
enables oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	IDA IDA: Inferred from direct assay	19442656	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in alcohol metabolic process	IDA IDA: Inferred from direct assay	18571493	GOA
involved in cellular ketone metabolic process	IDA IDA: Inferred from direct assay	18571493	GOA
involved in positive regulation of reactive oxygen species metabolic process	IDA IDA: Inferred from direct assay	19442656	GOA
involved in steroid metabolic process	IDA IDA: Inferred from direct assay	18571493	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	22227495	GOA
located in peroxisomal membrane	IDA IDA: Inferred from direct assay	10333503	GOA
located in peroxisome	IDA IDA: Inferred from direct assay	17230527	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DHRS4 Protein Structure

adh_short_C2

0
100
200
278 a.a.

Protein Preferred Names	Protein Names
dehydrogenase/reductase SDR family member 4	NADPH-dependent carbonyl reductase

Related Diseases

Diseases	Alias
Subjective Cognitive Decline

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03742	DHRS4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	DHRS4	MGD	MGI:90169
Rattus norvegicus	DHRS4	RGD	RGD:708482