Dnah5 - dynein, axonemal, heavy chain 5 Gene

Also Known as Dnahc5; Mdnah5; b2b601Clo; mKIAA1603; b2b1134Clo; b2b1154Clo; b2b1537Clo; b2b1565Clo; b2b3491Clo

Species: Mus musculus

Gene Type: protein coding
Gene ID: 110082

Summary

Enables microtubule motor activity. Acts upstream of or within several processes, including determination of left/right symmetry; epithelial cilium movement involved in extracellular fluid movement; and lateral ventricle development. Located in 9+2 motile cilium and axoneme. Part of outer dynein arm. Is expressed in gut; male reproductive gland or organ; midbrain; and trachea epithelium. Used to study otitis media; primary ciliary dyskinesia (multiple); tetralogy of Fallot; and visceral heterotaxy. Human ortholog(s) of this gene implicated in Kartagener syndrome and primary ciliary dyskinesia 3. Orthologous to human DNAH5 (dynein axonemal heavy chain 5). [provided by Alliance of Genome Resources, Apr 2022]

Dnah5 Products (1)

mRNA Protein Name
NM_133365.3 NP_579943.3 dynein axonemal heavy chain 5

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables microtubule motor activity IMP
IMP: Inferred from mutant phenotype
11912187 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
29916806 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cilium movement IMP
IMP: Inferred from mutant phenotype
11912187 MGI
acts upstream of or within determination of left/right symmetry IMP
IMP: Inferred from mutant phenotype
11912187 MGI
acts upstream of or within epithelial cilium movement involved in extracellular fluid movement IMP
IMP: Inferred from mutant phenotype
28289722 MGI
acts upstream of or within establishment of localization in cell IMP
IMP: Inferred from mutant phenotype
28289722 MGI
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
acts upstream of or within lateral ventricle development IMP
IMP: Inferred from mutant phenotype
11912187 MGI
Cellular Component GO Annotation Evidence References Source
located in 9+0 motile cilium IDA
IDA: Inferred from direct assay
33347437 MGI
located in 9+2 motile cilium IDA
IDA: Inferred from direct assay
23525783 MGI
part of axonemal dynein complex IMP
IMP: Inferred from mutant phenotype
11912187 MGI
located in axoneme IDA
IDA: Inferred from direct assay
23849778 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
29916806 MGI
part of outer dynein arm IDA
IDA: Inferred from direct assay
27353389 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

dynein axonemal heavy chain 5

dynein heavy chain 5, axonemal

  • axonemal beta dynein heavy chain 5

  • axonemal dynein heavy chain 5

  • ciliary dynein heavy chain 5

  • dynein, axon, heavy chain 5

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03850 DNAH5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dnah5 NCBI NCBI:1767