Rap1gap - Rap1 GTPase-activating protein Gene

Also Known as Gap; ARPP-90; Rap1ga1; Rap1GAP1; 1300019I11Rik; 2310004O14Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 110351

Summary

Predicted to enable GTPase activator activity; protein homodimerization activity; and small GTPase binding activity. Acts upstream of or within positive regulation of cell-cell adhesion and positive regulation of phagocytosis. Predicted to be located in several cellular components, including dendrite; early endosome; and neuronal cell body. Predicted to be active in cytoplasm and membrane. Is expressed in several structures, including metanephros; nervous system; olfactory epithelium; pancreas; and skeleton. Orthologous to human RAP1GAP (RAP1 GTPase activating protein). [provided by Alliance of Genome Resources, Apr 2022]

Rap1gap Products (8)

mRNA Protein Name
NM_001081155.3 NP_001074624.1 rap1 GTPase-activating protein 1 isoform 1
NM_001256218.2 NP_001243147.1 rap1 GTPase-activating protein 1 isoform 2
NM_001331215.1 NP_001318144.1 rap1 GTPase-activating protein 1 isoform 4
NM_001379233.1 NP_001366162.1 rap1 GTPase-activating protein 1 isoform 5
NM_001379234.1 NP_001366163.1 rap1 GTPase-activating protein 1 isoform 6
NM_001379235.1 NP_001366164.1 rap1 GTPase-activating protein 1 isoform 7
NM_001379236.1 NP_001366165.1 rap1 GTPase-activating protein 1 isoform 8
NM_029563.2 NP_083839.1 rap1 GTPase-activating protein 1 isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
24803656 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
24803656 MGI
acts upstream of establishment of localization in cell IMP
IMP: Inferred from mutant phenotype
24803656 MGI
acts upstream of phagocytosis IMP
IMP: Inferred from mutant phenotype
24803656 MGI
acts upstream of or within positive regulation of cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
24803656 MGI
acts upstream of or within positive regulation of phagocytosis IMP
IMP: Inferred from mutant phenotype
24803656 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

rap1 GTPase-activating protein 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11654 RAP1GAP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11655 RAP1GAP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22068 Rap1gap2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28586 Rap1gap2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rap1gap NCBI NCBI:5909