Adarb1 - adenosine deaminase, RNA-specific, B1 Gene

Also Known as Red1; Adar2; D10Bwg0447e; 1700057H01Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 110532

Summary

This gene encodes a double-stranded-RNA-specific Adenosine Deaminase that is involved in editing pre-mRNAs by site-specific conversion of adenosine (A) to inosine (I). Substrates for this enzyme include ionotropic glutamate receptors (GluR2-6) and serotonin receptor (5HT2C). Studies in rodents have shown that this protein can modify its own pre-mRNA by A->I editing to create a novel acceptor splice site, alternative splicing to which results in down regulation of its protein expression. Additional splicing events result in transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Adarb1 Products (6)

mRNA	Protein	Name
NM_001024837.2	NP_001020008.1	double-stranded RNA-specific editase 1 isoform 2
NM_001024838.2	NP_001020009.1	double-stranded RNA-specific editase 1 isoform 3
NM_130895.3	NP_570965.2	double-stranded RNA-specific editase 1 isoform 1
NM_001024837.2	NP_001020008.1	double-stranded RNA-specific editase 1 isoform 2
NM_001024838.2	NP_001020009.1	double-stranded RNA-specific editase 1 isoform 3
NM_130895.3	NP_570965.2	double-stranded RNA-specific editase 1 isoform 1

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	References	Source
involved in adenosine to inosine editing	IDA IDA: Inferred from direct assay	17369310	MGI
acts upstream of or within adenosine to inosine editing	IMP IMP: Inferred from mutant phenotype	20826656	MGI
acts upstream of or within facial nerve morphogenesis	IMP IMP: Inferred from mutant phenotype	20826656	MGI
acts upstream of or within hypoglossal nerve morphogenesis	IMP IMP: Inferred from mutant phenotype	20826656	MGI
acts upstream of or within innervation	IMP IMP: Inferred from mutant phenotype	20826656	MGI
acts upstream of or within motor behavior	IMP IMP: Inferred from mutant phenotype	20826656	MGI
acts upstream of or within motor neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	20826656	MGI
acts upstream of or within multicellular organism growth	IMP IMP: Inferred from mutant phenotype	20826656	MGI
acts upstream of or within muscle tissue morphogenesis	IMP IMP: Inferred from mutant phenotype	20826656	MGI
acts upstream of or within neuromuscular process controlling posture	IMP IMP: Inferred from mutant phenotype	20826656	MGI
acts upstream of or within neuromuscular synaptic transmission	IMP IMP: Inferred from mutant phenotype	20826656	MGI
acts upstream of or within spinal cord ventral commissure morphogenesis	IMP IMP: Inferred from mutant phenotype	20826656	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	20826656	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
double-stranded RNA-specific editase 1	RNA-editing deaminase 1 RNA-editing enzyme 1 dsRNA adenosine deaminase

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00318	ADARB1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Adarb1	NCBI	NCBI:104