Slc8a3 - solute carrier family 8 (sodium/calcium exchanger), member 3 Gene

Mus musculus

Also known as Ncx3

Gene ID: 110893 | Gene type: protein coding

About Slc8a3

Summary

Enables calcium:sodium antiporter activity and ion antiporter activity involved in regulation of postsynaptic membrane potential. Involved in several processes, including inorganic cation transmembrane transport; learning or memory; and nervous system development. Acts upstream of or within several processes, including hematopoietic progenitor cell differentiation; modulation of excitatory postsynaptic potential; and negative regulation of protein serine/threonine kinase activity. Located in several cellular components, including mitochondrial outer membrane; postsynaptic density; and sarcolemma. Is integral component of plasma membrane. Is expressed in several structures, including bone; brain; foregut; genitourinary system; and trachea. Orthologous to human SLC8A3 (solute carrier family 8 member A3). [provided by Alliance of Genome Resources, Apr 2022]

Slc8a3 Products(2)

mRNA	Protein	Name
NM_001167920.1	NP_001161392.1	sodium/calcium exchanger 3 isoform 1 precursor
NM_080440.3	NP_536688.2	sodium/calcium exchanger 3 isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium:monoatomic cation antiporter activity	IDA IDA: Inferred from direct assay	8798769	MGI
enables calcium:sodium antiporter activity	IMP IMP: Inferred from mutant phenotype	14722618	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in calcium ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	14722618	MGI
involved in cellular response to hypoxia	IDA IDA: Inferred from direct assay	24101730	MGI
acts upstream of or within hematopoietic progenitor cell differentiation	IMP IMP: Inferred from mutant phenotype	24029230	MGI
acts upstream of or within intracellular calcium ion homeostasis	IMP IMP: Inferred from mutant phenotype	29274751	MGI
involved in intracellular calcium ion homeostasis	IMP IMP: Inferred from mutant phenotype	14722618	MGI
involved in learning	IMP IMP: Inferred from mutant phenotype	21593315	MGI
acts upstream of or within learning or memory	IMP IMP: Inferred from mutant phenotype	29274751	MGI
acts upstream of or within long-term synaptic potentiation	IMP IMP: Inferred from mutant phenotype	29274751	MGI
involved in long-term synaptic potentiation	IMP IMP: Inferred from mutant phenotype	21593315	MGI
involved in memory	IMP IMP: Inferred from mutant phenotype	21593315	MGI
acts upstream of or within metal ion transport	IDA IDA: Inferred from direct assay	8798769	MGI
involved in mitochondrial calcium ion homeostasis	IMP IMP: Inferred from mutant phenotype	24101730	MGI
involved in mitochondrial calcium ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	24101730	MGI
acts upstream of or within modulation of excitatory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	29274751	MGI
involved in myelination	IMP IMP: Inferred from mutant phenotype	21959935	MGI
acts upstream of or within negative regulation of protein serine/threonine kinase activity	IMP IMP: Inferred from mutant phenotype	29274751	MGI
involved in oligodendrocyte differentiation	IMP IMP: Inferred from mutant phenotype	21959935	MGI
involved in regulation of skeletal muscle contraction	IMP IMP: Inferred from mutant phenotype	14722618	MGI
involved in sodium ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	14722618	MGI
acts upstream of or within synapse organization	IMP IMP: Inferred from mutant phenotype	29274751	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon terminus	IMP IMP: Inferred from mutant phenotype	29274751	MGI
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	24101730	MGI
located in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	24101730	MGI
located in neuromuscular junction	IDA IDA: Inferred from direct assay	14722618	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	24101730	MGI
located in postsynaptic density	IMP IMP: Inferred from mutant phenotype	29274751	MGI
located in sarcolemma	IDA IDA: Inferred from direct assay	14722618	MGI
located in synapse	IDA IDA: Inferred from direct assay	29274751	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

sodium/calcium exchanger 3

Na(+)/Ca(2+)-exchange protein 3

solute carrier family 8 member 3

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13339	SLC8A3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc8a3	NCBI	NCBI:6547

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