FOXN3 - forkhead box N3 Gene

Also Known as CHES1; PRO1635; C14orf116

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1112

About FOXN3

Cytogenetic location: 14q31.3-q32.11 Genomic coordinates (GRCh38): 14:89,156,177-89,619,165 (from NCBI)

This gene has 19 transcripts (splice variants), 208 orthologues and 2 paralogues. Ubiquitous expression in fat (RPKM 25.7), ovary (RPKM 24.3) and 25 other tissues.

Summary

This gene is a member of the forkhead/winged helix transcription factor family. Checkpoints are eukaryotic DNA damage-inducible cell cycle arrests at G1 and G2. Checkpoint suppressor 1 suppresses multiple yeast checkpoint mutations including mec1, rad9, rad53 and dun1 by activating a MEC1-independent checkpoint pathway. Alternative splicing is observed at the locus, resulting in distinct isoforms. [provided by RefSeq, Jul 2008]

FOXN3 Products (2)

mRNA Protein Name
NM_001085471.2 NP_001078940.1 forkhead box protein N3 isoform 1
NM_005197.4 NP_005188.2 forkhead box protein N3 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16102918 GOA
Biological Process GO Annotation Evidence References Source
involved in mitotic G2 DNA damage checkpoint signaling IGI
IGI: Inferred from genetic interaction
9154802 GOA
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
16102918 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FOXN3 Protein Structure

Forkhead

Forkhead: Forkhead domain (114 - 202)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 490 a.a.
Protein Preferred Names Protein Names

forkhead box protein N3

  • checkpoint suppressor 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05067 FOXN3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22514 Foxn3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29035 Foxn3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus FOXN3 VGNC VGNC:62341
Canis familiaris FOXN3 VGNC VGNC:49737
Mus musculus FOXN3 MGD MGI:1918625
Macaca mulatta FOXN3 VGNC VGNC:72535
Rattus norvegicus FOXN3 RGD RGD:1305711
Bos taurus FOXN3 VGNC VGNC:55115
Others FOXN3 NCBI