SOX21 - SRY-box transcription factor 21 Gene

Also Known as SOX25

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 11166

About SOX21

Cytogenetic location: 13q32.1 Genomic coordinates (GRCh38): 13:94,709,622-94,712,545 (from NCBI)

This gene has 1 transcript (splice variant), 164 orthologues, 20 paralogues and is associated with 37 phenotypes.

Summary

SRY-related HMG-box (SOX) genes encode a family of DNA-binding proteins containing a 79-amino acid HMG (high mobility group) domain that shares at least 50% sequence identity with the DNA-binding HMG box of the SRY protein (MIM 480000). SOX proteins are divided into 6 subgroups based on sequence similarity within and outside of the HMG domain. For additional background information on SOX genes, see SOX1 (MIM 602148).[supplied by OMIM, Apr 2004]

SOX21 Products (1)

mRNA Protein Name
NM_007084.4 NP_009015.1 transcription factor SOX-21

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in stem cell differentiation IDA
IDA: Inferred from direct assay
20876214 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SOX21 Protein Structure

HMG_box

HMG_box: HMG (high mobility group) box (8 - 76)

SOXp

SOXp: SOX transcription factor (77 - 95)

  • 0
  • 100
  • 200
  • 276 a.a.
Protein Preferred Names Protein Names

transcription factor SOX-21

  • SOX-A

Related Diseases

Diseases Alias
Lambert-Eaton Myasthenic Syndrome

  • Lambert-Eaton Syndrome

  • Eaton-Lambert Syndrome

  • Lems

  • Lambert Eaton Myasthenic Syndrome

  • Eaton Lambert Syndrome

  • Lambert Eaton Syndrome

  • Myasthenic Syndrome Of Lambert-Eaton

  • Myasthenic-Myopathic Syndrome Of Lambert-Eaton

  • Lems - [Lambert-Eaton Myasthenic Syndrome]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13592 SOX21 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18684 Sox10 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus SOX21 VGNC VGNC:102327
Mus musculus SOX21 MGD MGI:2654070
Bos taurus SOX21 VGNC VGNC:35147
Macaca mulatta SOX21 VGNC VGNC:106298
Rattus norvegicus SOX21 RGD RGD:1304724
Others SOX21 NCBI