Dxo - decapping exoribonuclease Gene

Also Known as NG6; Dom3z

Species: Mus musculus

Gene Type: protein coding
Gene ID: 112403

Summary

Enables several functions, including 5'-3' exonuclease activity; hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; and magnesium ion binding activity. Involved in RNA destabilization and nucleic acid metabolic process. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be active in cytosol and nucleus. Orthologous to human DXO (decapping exoribonuclease). [provided by Alliance of Genome Resources, Apr 2022]

Dxo Products (4)

mRNA Protein Name
NM_001163770.2 NP_001157242.1 decapping and exoribonuclease protein isoform 1
NM_001413617.1 NP_001400546.1 decapping and exoribonuclease protein isoform 2
NM_001413618.1 NP_001400547.1 decapping and exoribonuclease protein isoform 2
NM_033613.3 NP_291091.2 decapping and exoribonuclease protein isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables 5'-3' exonuclease activity IDA
IDA: Inferred from direct assay
23523372 MGI
enables RNA NAD+-cap (NAD+-forming) hydrolase activity IDA
IDA: Inferred from direct assay
28283058 MGI
enables mRNA 5'-diphosphatase activity IDA
IDA: Inferred from direct assay
23523372 MGI
enables mRNA binding IDA
IDA: Inferred from direct assay
23523372 MGI
enables magnesium ion binding IDA
IDA: Inferred from direct assay
23523372 MGI
Biological Process GO Annotation Evidence References Source
involved in NAD-cap decapping IDA
IDA: Inferred from direct assay
28283058 MGI
involved in RNA destabilization IMP
IMP: Inferred from mutant phenotype
23523372 MGI
involved in mRNA catabolic process IDA
IDA: Inferred from direct assay
28283058 MGI
involved in mRNA catabolic process IMP
IMP: Inferred from mutant phenotype
23523372 MGI
involved in nuclear mRNA surveillance IMP
IMP: Inferred from mutant phenotype
23523372 MGI
involved in nucleic acid metabolic process IDA
IDA: Inferred from direct assay
23523372 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

decapping and exoribonuclease protein

  • 5'-3' exoribonuclease DXO

  • NAD-capped RNA hydrolase DXO

  • deNADding enzyme DXO

  • protein Dom3Z

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04079 DXO Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dxo NCBI NCBI:1797