PMF1 - polyamine modulated factor 1 Gene

Homo sapiens

Gene ID: 11243 | Gene type: protein coding

About PMF1

Cytogenetic location: 1q22 Genomic coordinates (GRCh38): 1:156,213,007-156,240,042 (from NCBI)

This gene has 6 transcripts (splice variants) and 134 orthologues. Ubiquitous expression in bone marrow (RPKM 21.9), thyroid (RPKM 21.3) and 25 other tissues.

Summary

Enables leucine zipper domain binding activity and transcription coactivator activity. Involved in chromosome segregation. Located in Golgi apparatus; kinetochore; and nucleoplasm. Part of MIS12/MIND type complex. Implicated in bladder carcinoma and urinary bladder Cancer. [provided by Alliance of Genome Resources, Apr 2022]

PMF1 Products(10)

mRNA	Protein	Name
NM_001199653.2	NP_001186582.1	polyamine-modulated factor 1 isoform 3
NM_001199654.2	NP_001186583.1	polyamine-modulated factor 1 isoform 1
NM_001393909.1	NP_001380838.1	polyamine-modulated factor 1 isoform 4
NM_001393910.1	NP_001380839.1	polyamine-modulated factor 1 isoform 5
NM_001393911.1	NP_001380840.1	polyamine-modulated factor 1 isoform 6
NM_001393912.1	NP_001380841.1	polyamine-modulated factor 1 isoform 7
NM_001393913.1	NP_001380842.1	polyamine-modulated factor 1 isoform 8
NM_001393914.1	NP_001380843.1	polyamine-modulated factor 1 isoform 9
NM_001393915.1	NP_001380844.1	polyamine-modulated factor 1 isoform 10
NM_007221.4	NP_009152.2	polyamine-modulated factor 1 isoform 2

PMF1 Protein Structure

Nnf1

0
100
205 a.a.

Protein Preferred Names

Protein Names

polyamine-modulated factor 1

Est1p-like protein B (EST1B)

Related Diseases

Diseases

Alias

Phototoxic Dermatitis

Dermatitis, Phototoxic	Photosensitisation Reaction
Photosensitive Dermatitis	Photosensitiveness

Cerebral Arteriopathy, Autosomal Dominant, With Subcortical Infarcts And Leukoencephalopathy, Type 1

Cadasil	Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts And Leukoencephalopathy
Casil	Cerebral Arteriopathy With Subcortical Infarcts And Leukoencephalopathy
Familial Vascular Leukoencephalopathy	CADASIL1
Cadasil 1	Hereditary Multi-Infarct Dementia
Cadasil Syndrome	Dementia, Hereditary Multiinfarct Type
Cerebral Arteriopathy With Subcortical Infarcts And Leukoencephalopathy 1	Autosomal Dominant Cerebral Arteriopathy With Subcortical Infarcts And Leukoencephalopathy Type 1
Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts Leukoencephalopathy	Dementia, Hereditary Multi-Infarct Type
Hereditary Dementia, Multi-Infarct Type	Cerebral Autosomal Dominant Arteriopathy-Subcortical Infarcts-Leukoencephalopathy
Cerebral Arteriopathy, Autosomal Dominant, With Subcortical Infarcts And Leukoencephalopathy, 1	Cerebral Arteriopathy With Subcortical Infarcts And Leukoencephalopathy, Autosomal Dominant
Dementia Hereditary Multiinfarct Type	Dementia Hereditary Multi-Infarct Type
Arteriopathy, Cerebral, Autosomal Dominant, With Subcortical Infarcts And Leukoencephalopathy

Bladder Cancer

Urinary Bladder Cancer	Bladder Carcinoma
Urinary Bladder Carcinoma	Bladder Neoplasm
Bladder Tumor	Cancer, Bladder
Malignant Neoplasm Of Urinary Bladder	Carcinoma Of Bladder
Bladder Cancer, Somatic	Tumor Of The Bladder
Carcinoma Of Urinary Bladder	Bladder Carcinoma Urinary
Cancer Of The Urinary Bladder	Cancer, Urinary Bladder
Malignant Bladder Neoplasm	Malignant Bladder Tumor
Neoplasm Of The Bladder	Neoplasm Of The Urinary Bladder
Tumor Of The Urinary Bladder	Urinary Bladder Neoplasm
BLC	Urothelial Carcinoma Of The Bladder
Bladder Tumors	Urinary Bladder Neoplasms
Bladder Cancer Nos	Vesical Cancer Nos
Malignant Neoplasm Of Bladder, Part Unspecified	Malignant Tumour Of Urinary Bladder
Primary Malignant Neoplasm Of Bladder

Plasmodium Malariae Malaria

Quartan Malaria	Malaria By Plasmodium Malariae
Nephrotic Syndrome Of Quartan Malaria	Malaria Nephrosis
Malarial Nephrosis	Nephrotic Syndrome In Malaria
Quartan Nephrosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10762	PMF1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PMF1	RGD	RGD:1584694
Mus musculus	PMF1	MGD	MGI:1914287
Others	PMF1	NCBI