SHLD3 - shieldin complex subunit 3 Gene

Also Known as RINN1; CTC-534A2.2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 112441434

About SHLD3

Cytogenetic location: 5q12.3 Genomic coordinates (GRCh38): 5:65,625,027-65,630,928 (from NCBI)

This gene has 2 transcripts (splice variants) and 92 orthologues.

Summary

Involved in negative regulation of double-strand break repair via homologous recombination; positive regulation of double-strand break repair via nonhomologous end joining; and positive regulation of isotype switching. Located in site of double-strand break. [provided by Alliance of Genome Resources, Apr 2022]

SHLD3 Products (1)

mRNA Protein Name
NM_001365341.2 NP_001352270.1 shieldin complex subunit 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
29656893 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of double-strand break repair via homologous recombination IDA
IDA: Inferred from direct assay
29656893 GOA
involved in positive regulation of double-strand break repair via nonhomologous end joining IDA
IDA: Inferred from direct assay
29656893 GOA
involved in positive regulation of isotype switching IDA
IDA: Inferred from direct assay
29656893 GOA
Cellular Component GO Annotation Evidence References Source
located in chromosome IDA
IDA: Inferred from direct assay
29656893 GOA
located in site of double-strand break IDA
IDA: Inferred from direct assay
29656893 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

shieldin complex subunit 3

  • REV7-interacting novel NHEJ regulator 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12875 SHLD3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SHLD3 RGD RGD:41350418
Mus musculus SHLD3 MGD MGI:6194609