ADCY7 - adenylate cyclase 7 Gene

Also Known as AC7

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 113

About ADCY7

Cytogenetic location: 16q12.1 Genomic coordinates (GRCh38): 16:50,244,699-50,318,135 (from NCBI)

This gene has 16 transcripts (splice variants), 203 orthologues and 17 paralogues. Broad expression in spleen (RPKM 22.5), appendix (RPKM 19.0) and 24 other tissues.

Summary

This gene encodes a membrane-bound Adenylate Cyclase that catalyses the formation of cyclic AMP from ATP and is inhibitable by calcium. The product of this gene is a member of the adenylyl cyclase class-4/guanylyl cyclase enzyme family that is characterized by the presence of twelve membrane-spanning domains in its sequences. Several transcript variants have been observed for this gene, but the full-length natures of only two have been determined so far. [provided by RefSeq, Oct 2013]

ADCY7 Products (2)

mRNA Protein Name
NM_001114.5 NP_001105.1 adenylate cyclase type 7 isoform 1
NM_001286057.2 NP_001272986.1 adenylate cyclase type 7 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables adenylate cyclase activity IDA
IDA: Inferred from direct assay
11113152 GOA
enables adenylate cyclase activity IMP
IMP: Inferred from mutant phenotype
18541530 GOA
Biological Process GO Annotation Evidence References Source
involved in cAMP biosynthetic process IDA
IDA: Inferred from direct assay
11113152 GOA
involved in cellular response to ethanol IDA
IDA: Inferred from direct assay
12454008 GOA
Cellular Component GO Annotation Evidence References Source
located in membrane IDA
IDA: Inferred from direct assay
11113152 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADCY7 Protein Structure

Guanylate_cyc

Guanylate_cyc: Adenylate and Guanylate cyclase catalytic domain (271 - 430)

DUF1053

DUF1053: Domain of Unknown Function (DUF1053) (485 - 591)

Guanylate_cyc

Guanylate_cyc: Adenylate and Guanylate cyclase catalytic domain (871 - 1067)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1080 a.a.
Protein Preferred Names Protein Names

adenylate cyclase type 7

  • ATP pyrophosphate-lyase 7

Related Diseases

Diseases Alias
Leber Congenital Amaurosis 1

  • LCA1

  • Amaurosis Congenita Of Leber I

  • Lca

  • Retinal Blindness, Congenital

  • Crb

  • Leber Congenital Amaurosis Type I

  • Leber Congenital Amaurosis, Type 1

  • Amaurosis Congenita Of Leber, Type 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00333 ADCY7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus ADCY7 VGNC VGNC:59620
Macaca mulatta ADCY7 VGNC VGNC:69515
Bos taurus ADCY7 VGNC VGNC:25648
Mus musculus ADCY7 MGD MGI:102891
Rattus norvegicus ADCY7 RGD RGD:619966
Canis familiaris ADCY7 VGNC VGNC:37624
Others ADCY7 NCBI