2. Gene
  3. Abca2 - ATP-binding cassette, sub-family A (ABC1), member 2 Gene

Abca2 - ATP-binding cassette, sub-family A (ABC1), member 2 Gene

  • Gene
  • Protein
Mus musculus

Also known as Abc2; mKIAA1062; D2H0S1474E

Gene ID: 11305 | Gene type: protein coding

About Abca2

Summary

Predicted to enable several functions, including ATP binding activity; ceramide floppase activity; and endopeptidase regulator activity. Involved in several processes, including regulation of intracellular Cholesterol transport; regulation of protein glycosylation; and sphingolipid metabolic process. Acts upstream of or within central nervous system myelin formation. Located in lysosomal membrane. Is expressed in brain; retina; and spinal cord. Orthologous to human ABCA2 (ATP binding cassette subfamily A member 2). [provided by Alliance of Genome Resources, Apr 2022]

Abca2 Products(2)

mRNA Protein Name
NM_001368624.1 NP_001355553.1 ATP-binding cassette sub-family A member 2 isoform 2
NM_007379.3 NP_031405.2 ATP-binding cassette sub-family A member 2 isoform 1
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within central nervous system myelin formation IMP
IMP: Inferred from mutant phenotype
17060448 MGI
involved in ganglioside metabolic process IMP
IMP: Inferred from mutant phenotype
17488728 MGI
involved in glycosphingolipid metabolic process IMP
IMP: Inferred from mutant phenotype
17488728 MGI
involved in locomotory behavior IMP
IMP: Inferred from mutant phenotype
17060448 MGI
acts upstream of negative regulation of low-density lipoprotein receptor activity IDA
IDA: Inferred from direct assay
21810484 MGI
involved in regulation of intracellular cholesterol transport IMP
IMP: Inferred from mutant phenotype
22748276 MGI
involved in regulation of protein glycosylation IMP
IMP: Inferred from mutant phenotype
22086926 MGI
involved in regulation of protein localization to cell periphery IMP
IMP: Inferred from mutant phenotype
22086926 MGI
involved in regulation of protein localization to cell surface IMP
IMP: Inferred from mutant phenotype
22086926 MGI
involved in sphingomyelin metabolic process IMP
IMP: Inferred from mutant phenotype
17488728 MGI
Cellular Component GO Annotation Evidence Reference Source
located in lysosomal membrane IDA
IDA: Inferred from direct assay
11157071 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ATP-binding cassette sub-family A member 2

ATP-binding cassette 2

ATP-binding cassette transporter 2