Inpp5e - inositol polyphosphate-5-phosphatase E Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 114089

Summary

Enables inositol-polyphosphate 5-phosphatase activity; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity; and phosphatidylinositol-4,5-bisphosphate Phosphatase activity. Involved in negative regulation of phosphatidylinositol 3-kinase signaling and negative regulation of translation. Located in cytoplasm; plasma membrane; and ruffle. Biomarker of obesity. Human ortholog(s) of this gene implicated in Joubert syndrome and Joubert syndrome 1. Orthologous to human INPP5E (inositol polyphosphate-5-phosphatase E). [provided by Alliance of Genome Resources, Apr 2022]

Inpp5e Products (1)

mRNA Protein Name
NM_053632.1 NP_446084.1 phosphatidylinositol polyphosphate 5-phosphatase type IV

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables inositol-polyphosphate 5-phosphatase activity IDA
IDA: Inferred from direct assay
10405344 RGD
enables phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity IDA
IDA: Inferred from direct assay
21436142 RGD
enables phosphatidylinositol-4,5-bisphosphate phosphatase activity IDA
IDA: Inferred from direct assay
21436142 RGD
Biological Process GO Annotation Evidence References Source
involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
IDA: Inferred from direct assay
21436142 RGD
involved in negative regulation of translation IDA
IDA: Inferred from direct assay
21436142 RGD
Cellular Component GO Annotation Evidence References Source
located in ruffle IDA
IDA: Inferred from direct assay
10405344 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

phosphatidylinositol polyphosphate 5-phosphatase type IV

  • 5-phosphatase that induces arborization

  • 72 kDa inositol polyphosphate 5-phosphatase

  • inositol polyphosphate 5-phosphatase

  • pharbin

  • phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase

  • phosphatidylinositol-4,5-bisphosphate 5-phosphatase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06830 INPP5E Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10770 PMPCA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21143 Inpp5e Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27660 Inpp5e Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Inpp5e NCBI NCBI:56623