Chrna4 - cholinergic receptor, nicotinic, alpha polypeptide 4 Gene

Also Known as EBN1; Acra4; ENFL1; Acra-4

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11438

Summary

Enables acetylcholine-gated cation-selective channel activity. Contributes to acetylcholine receptor activity. Involved in regulation of synaptic vesicle exocytosis. Acts upstream of or within several processes, including behavioral response to nicotine; chemical synaptic transmission; and regulation of dopamine secretion. Located in dopaminergic synapse and external side of plasma membrane. Part of acetylcholine-gated channel complex. Is integral component of presynaptic membrane. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant nocturnal frontal lobe epilepsy 1 and nicotine dependence. Orthologous to human CHRNA4 (cholinergic receptor nicotinic alpha 4 subunit). [provided by Alliance of Genome Resources, Apr 2022]

Chrna4 Products (1)

mRNA Protein Name
NM_015730.5 NP_056545.3 neuronal acetylcholine receptor subunit alpha-4 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
contributes to acetylcholine receptor activity IDA
IDA: Inferred from direct assay
12871652 MGI
enables acetylcholine-gated monoatomic cation-selective channel activity IGI
IGI: Inferred from genetic interaction
15569257 MGI
enables acetylcholine-gated monoatomic cation-selective channel activity IMP
IMP: Inferred from mutant phenotype
11222635 MGI
enables monoatomic ion channel activity IDA
IDA: Inferred from direct assay
11906696 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11906696 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within B cell activation IMP
IMP: Inferred from mutant phenotype
15963492 MGI
acts upstream of or within acetylcholine receptor signaling pathway IDA
IDA: Inferred from direct assay
26276394 MGI
acts upstream of or within behavioral response to nicotine IMP
IMP: Inferred from mutant phenotype
15528443 MGI
acts upstream of or within calcium ion transport IGI
IGI: Inferred from genetic interaction
15569257 MGI
acts upstream of or within exploration behavior IMP
IMP: Inferred from mutant phenotype
10964949 MGI
acts upstream of or within inhibitory postsynaptic potential IMP
IMP: Inferred from mutant phenotype
17146052 MGI
acts upstream of or within locomotory behavior IMP
IMP: Inferred from mutant phenotype
11226318 MGI
acts upstream of or within membrane depolarization IGI
IGI: Inferred from genetic interaction
15741168 MGI
acts upstream of or within membrane depolarization IMP
IMP: Inferred from mutant phenotype
11222635 MGI
acts upstream of or within nervous system process IMP
IMP: Inferred from mutant phenotype
17146052 MGI
acts upstream of or within neuronal action potential IMP
IMP: Inferred from mutant phenotype
10235262 MGI
involved in presynaptic modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
12944511 MGI
involved in presynaptic modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
12944511 MGI
acts upstream of or within regulation of dopamine secretion IMP
IMP: Inferred from mutant phenotype
12944511 MGI
acts upstream of or within regulation of membrane potential IGI
IGI: Inferred from genetic interaction
15569257 MGI
acts upstream of or within respiratory gaseous exchange by respiratory system IMP
IMP: Inferred from mutant phenotype
21606356 MGI
acts upstream of or within response to nicotine IDA
IDA: Inferred from direct assay
12871652 MGI
acts upstream of or within response to nicotine IGI
IGI: Inferred from genetic interaction
15741168 MGI
acts upstream of or within response to nicotine IMP
IMP: Inferred from mutant phenotype
10235262 MGI
acts upstream of or within sensory perception of pain IMP
IMP: Inferred from mutant phenotype
10235262 MGI
acts upstream of or within synaptic transmission, cholinergic IDA
IDA: Inferred from direct assay
11906696 MGI
acts upstream of or within synaptic transmission, cholinergic IMP
IMP: Inferred from mutant phenotype
11226318 MGI
Cellular Component GO Annotation Evidence References Source
part of acetylcholine-gated channel complex IDA
IDA: Inferred from direct assay
12871652 MGI
part of acetylcholine-gated channel complex IPI
IPI: Inferred from physical interaction
17434683 MGI
is active in dopaminergic synapse IDA
IDA: Inferred from direct assay
12944511 MGI
is active in dopaminergic synapse IMP
IMP: Inferred from mutant phenotype
12944511 MGI
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
15963492 MGI
located in membrane IDA
IDA: Inferred from direct assay
11906696 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
15741168 MGI
is active in presynaptic membrane IDA
IDA: Inferred from direct assay
24607281 MGI
is active in presynaptic membrane IEP
IEP: Inferred from expression pattern
24607281 MGI
is active in presynaptic membrane IMP
IMP: Inferred from mutant phenotype
29114204 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neuronal acetylcholine receptor subunit alpha-4

  • a4 nicotinic receptor

  • acetylcholine receptor alpha 4 neural

  • acetylcholine receptor, neuronal, nicotinic, alpha-4 subunit

  • alpha4 nAChR

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02669 CHRNA4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Chrna4 NCBI NCBI:1137