Chrna6 - cholinergic receptor, nicotinic, alpha polypeptide 6 Gene

Also Known as Acra6; Nica6

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11440

Summary

Enables acetylcholine-gated cation-selective channel activity. Involved in regulation of synaptic vesicle exocytosis. Acts upstream of or within membrane depolarization and regulation of dopamine secretion. Located in dopaminergic synapse. Part of acetylcholine-gated channel complex. Is integral component of postsynaptic membrane and integral component of presynaptic membrane. Is expressed in central nervous system and retina. Orthologous to human CHRNA6 (cholinergic receptor nicotinic alpha 6 subunit). [provided by Alliance of Genome Resources, Apr 2022]

Chrna6 Products (1)

mRNA Protein Name
NM_021369.2 NP_067344.2 neuronal acetylcholine receptor subunit alpha-6 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables acetylcholine-gated monoatomic cation-selective channel activity IMP
IMP: Inferred from mutant phenotype
11850448 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12944511 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within membrane depolarization IMP
IMP: Inferred from mutant phenotype
12944511 MGI
involved in presynaptic modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
12944511 MGI
involved in presynaptic modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
12944511 MGI
acts upstream of or within regulation of dopamine secretion IMP
IMP: Inferred from mutant phenotype
12944511 MGI
Cellular Component GO Annotation Evidence References Source
part of acetylcholine-gated channel complex IDA
IDA: Inferred from direct assay
12944511 MGI
is active in dopaminergic synapse IDA
IDA: Inferred from direct assay
12944511 MGI
is active in dopaminergic synapse IMP
IMP: Inferred from mutant phenotype
12944511 MGI
is active in postsynaptic membrane IDA
IDA: Inferred from direct assay
24607281 MGI
is active in postsynaptic membrane IEP
IEP: Inferred from expression pattern
24607281 MGI
is active in presynaptic membrane IDA
IDA: Inferred from direct assay
24607281 MGI
is active in presynaptic membrane IEP
IEP: Inferred from expression pattern
24607281 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neuronal acetylcholine receptor subunit alpha-6

  • acetylcholine receptor alpha 6 neural

  • alpha6 nAChR

  • nicotinic acetylcholine receptor subunit alpha 6

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02671 CHRNA6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Chrna6 NCBI NCBI:8973