Chrna6 - cholinergic receptor, nicotinic, alpha polypeptide 6 Gene

Mus musculus

Also known as Acra6; Nica6

Gene ID: 11440 | Gene type: protein coding

About Chrna6

Summary

Enables acetylcholine-gated cation-selective channel activity. Involved in regulation of synaptic vesicle exocytosis. Acts upstream of or within membrane depolarization and regulation of dopamine secretion. Located in dopaminergic synapse. Part of acetylcholine-gated channel complex. Is integral component of postsynaptic membrane and integral component of presynaptic membrane. Is expressed in central nervous system and retina. Orthologous to human CHRNA6 (cholinergic receptor nicotinic alpha 6 subunit). [provided by Alliance of Genome Resources, Apr 2022]

Chrna6 Products(1)

mRNA	Protein	Name
NM_021369.2	NP_067344.2	neuronal acetylcholine receptor subunit alpha-6 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables acetylcholine-gated monoatomic cation-selective channel activity	IMP IMP: Inferred from mutant phenotype	11850448	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12944511	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within membrane depolarization	IMP IMP: Inferred from mutant phenotype	12944511	MGI
involved in presynaptic modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	12944511	MGI
involved in presynaptic modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	12944511	MGI
acts upstream of or within regulation of dopamine secretion	IMP IMP: Inferred from mutant phenotype	12944511	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of acetylcholine-gated channel complex	IDA IDA: Inferred from direct assay	12944511	MGI
is active in dopaminergic synapse	IDA IDA: Inferred from direct assay	12944511	MGI
is active in dopaminergic synapse	IMP IMP: Inferred from mutant phenotype	12944511	MGI
is active in postsynaptic membrane	IDA IDA: Inferred from direct assay	24607281	MGI
is active in postsynaptic membrane	IEP IEP: Inferred from expression pattern	24607281	MGI
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	24607281	MGI
is active in presynaptic membrane	IEP IEP: Inferred from expression pattern	24607281	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

neuronal acetylcholine receptor subunit alpha-6

acetylcholine receptor alpha 6 neural	alpha6 nAChR
nicotinic acetylcholine receptor subunit alpha 6

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02671	CHRNA6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Chrna6	NCBI	NCBI:8973

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