2. Gene
  3. Chrnb1 - cholinergic receptor, nicotinic, beta polypeptide 1 (muscle) Gene

Chrnb1 - cholinergic receptor, nicotinic, beta polypeptide 1 (muscle) Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Acrb; Achr-2

Gene ID: 11443 | Gene type: protein coding

About Chrnb1

Summary

Enables acetylcholine binding activity and acetylcholine-gated cation-selective channel activity. Acts upstream of or within regulation of membrane potential. Located in plasma membrane. Is integral component of postsynaptic specialization membrane. Part of acetylcholine-gated channel complex. Is active in neuromuscular junction. Is expressed in several structures, including forelimb bud; limb segment; lung; paraxial mesenchyme; and skeletal musculature. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 2A and congenital myasthenic syndrome 2C. Orthologous to human CHRNB1 (cholinergic receptor nicotinic beta 1 subunit). [provided by Alliance of Genome Resources, Apr 2022]

Chrnb1 Products(1)

mRNA Protein Name
NM_009601.4 NP_033731.3 acetylcholine receptor subunit beta precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables acetylcholine binding IMP
IMP: Inferred from mutant phenotype
8872460 MGI
contributes to acetylcholine-gated monoatomic cation-selective channel activity IGI
IGI: Inferred from genetic interaction
2383398 MGI
enables acetylcholine-gated monoatomic cation-selective channel activity IGI
IGI: Inferred from genetic interaction
8798466 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
8798466 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within regulation of membrane potential IGI
IGI: Inferred from genetic interaction
2383398 MGI
Cellular Component GO Annotation Evidence Reference Source
part of acetylcholine-gated channel complex IDA
IDA: Inferred from direct assay
8798466 MGI
is active in neuromuscular junction IDA
IDA: Inferred from direct assay
4781450 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
12388596 MGI
is active in postsynaptic specialization membrane IDA
IDA: Inferred from direct assay
4781450 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

acetylcholine receptor subunit beta

AChR beta

acetylcholine receptor beta

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02674 CHRNB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Chrnb1 NCBI NCBI:1140