Chrnb2 - cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal) Gene

Mus musculus

Also known as Acrb2; Acrb-2; [b]2-nAchR; C030030P04Rik

Gene ID: 11444 | Gene type: protein coding

About Chrnb2

Summary

Enables acetylcholine-gated cation-selective channel activity. Involved in regulation of synaptic vesicle exocytosis. Acts upstream of or within several processes, including learning or memory; nervous system development; and regulation of circadian sleep/wake cycle, sleep. Located in external side of plasma membrane. Is integral component of postsynaptic specialization membrane and integral component of presynaptic membrane. Part of acetylcholine-gated channel complex. Is active in cholinergic synapse and dopaminergic synapse. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Used to study attention deficit hyperactivity disorder; autism spectrum disorder; and autosomal dominant nocturnal frontal lobe epilepsy 3. Human ortholog(s) of this gene implicated in autosomal dominant nocturnal frontal lobe epilepsy and autosomal dominant nocturnal frontal lobe epilepsy 3. Orthologous to human CHRNB2 (cholinergic receptor nicotinic beta 2 subunit). [provided by Alliance of Genome Resources, Apr 2022]

Chrnb2 Products(1)

mRNA	Protein	Name
NM_009602.4	NP_033732.2	neuronal acetylcholine receptor subunit beta-2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables acetylcholine-gated monoatomic cation-selective channel activity	IDA IDA: Inferred from direct assay	9614223	MGI
enables acetylcholine-gated monoatomic cation-selective channel activity	IGI IGI: Inferred from genetic interaction	15569257	MGI
enables acetylcholine-gated monoatomic cation-selective channel activity	IMP IMP: Inferred from mutant phenotype	11222635	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12944511	MGI
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IDA IDA: Inferred from direct assay	23811311	MGI
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IMP IMP: Inferred from mutant phenotype	23811311	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within B cell activation	IMP IMP: Inferred from mutant phenotype	15963492	MGI
acts upstream of B cell proliferation	IGI IGI: Inferred from genetic interaction	15963492	MGI
acts upstream of or within acetylcholine receptor signaling pathway	IDA IDA: Inferred from direct assay	26276394	MGI
acts upstream of action potential	IMP IMP: Inferred from mutant phenotype	15456819	MGI
acts upstream of or within associative learning	IGI IGI: Inferred from genetic interaction	15541879	MGI
acts upstream of or within behavioral response to nicotine	IMP IMP: Inferred from mutant phenotype	11955523	MGI
acts upstream of or within calcium ion transport	IGI IGI: Inferred from genetic interaction	15569257	MGI
acts upstream of or within central nervous system neuron axonogenesis	IMP IMP: Inferred from mutant phenotype	12097474	MGI
acts upstream of or within central nervous system projection neuron axonogenesis	IMP IMP: Inferred from mutant phenotype	11344259	MGI
acts upstream of or within conditioned taste aversion	IMP IMP: Inferred from mutant phenotype	11955523	MGI
acts upstream of dopamine secretion	IMP IMP: Inferred from mutant phenotype	9428762	MGI
acts upstream of establishment of localization in cell	IMP IMP: Inferred from mutant phenotype	9428762	MGI
acts upstream of or within lateral geniculate nucleus development	IMP IMP: Inferred from mutant phenotype	12097474	MGI
acts upstream of or within learning	IMP IMP: Inferred from mutant phenotype	11044747	MGI
acts upstream of or within locomotory behavior	IMP IMP: Inferred from mutant phenotype	9428762	MGI
acts upstream of or within membrane depolarization	IMP IMP: Inferred from mutant phenotype	11222635	MGI
acts upstream of or within memory	IMP IMP: Inferred from mutant phenotype	7870173	MGI
acts upstream of or within negative regulation of neuronal action potential	IMP IMP: Inferred from mutant phenotype	15456819	MGI
acts upstream of or within neuronal action potential	IGI IGI: Inferred from genetic interaction	10531434	MGI
acts upstream of neuronal action potential	IMP IMP: Inferred from mutant phenotype	15456819	MGI
acts upstream of or within neuronal action potential	IMP IMP: Inferred from mutant phenotype	10235262	MGI
acts upstream of or within optic nerve morphogenesis	IMP IMP: Inferred from mutant phenotype	11344259	MGI
acts upstream of or within positive regulation of B cell proliferation	IGI IGI: Inferred from genetic interaction	15963492	MGI
acts upstream of or within positive regulation of dopamine secretion	IMP IMP: Inferred from mutant phenotype	9428762	MGI
acts upstream of or within positive regulation of synaptic transmission, dopaminergic	IMP IMP: Inferred from mutant phenotype	15464132	MGI
involved in presynaptic modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	11145999	MGI
involved in presynaptic modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	11145999	MGI
acts upstream of or within regulation of circadian sleep/wake cycle, REM sleep	IMP IMP: Inferred from mutant phenotype	15215293	MGI
acts upstream of or within regulation of circadian sleep/wake cycle, non-REM sleep	IMP IMP: Inferred from mutant phenotype	15215293	MGI
acts upstream of or within regulation of dendrite morphogenesis	IMP IMP: Inferred from mutant phenotype	11027228	MGI
acts upstream of or within regulation of dopamine metabolic process	IMP IMP: Inferred from mutant phenotype	11282258	MGI
acts upstream of or within regulation of dopamine secretion	IMP IMP: Inferred from mutant phenotype	12944511	MGI
acts upstream of or within regulation of membrane potential	IGI IGI: Inferred from genetic interaction	10531434	MGI
acts upstream of or within regulation of membrane potential	IMP IMP: Inferred from mutant phenotype	9428762	MGI
acts upstream of or within regulation of synapse assembly	IMP IMP: Inferred from mutant phenotype	17301182	MGI
acts upstream of or within regulation of synaptic transmission, dopaminergic	IMP IMP: Inferred from mutant phenotype	16772172	MGI
acts upstream of or within response to cocaine	IMP IMP: Inferred from mutant phenotype	11282258	MGI
acts upstream of or within response to ethanol	IMP IMP: Inferred from mutant phenotype	15489024	MGI
acts upstream of or within response to hypoxia	IMP IMP: Inferred from mutant phenotype	15450117	MGI
acts upstream of or within response to nicotine	IGI IGI: Inferred from genetic interaction	10531434	MGI
acts upstream of or within response to nicotine	IMP IMP: Inferred from mutant phenotype	9428762	MGI
acts upstream of or within sensory perception of pain	IMP IMP: Inferred from mutant phenotype	10235262	MGI
acts upstream of or within sensory perception of sound	IMP IMP: Inferred from mutant phenotype	15788760	MGI
acts upstream of or within smooth muscle contraction	IGI IGI: Inferred from genetic interaction	10531434	MGI
acts upstream of or within social behavior	IMP IMP: Inferred from mutant phenotype	12876201	MGI
acts upstream of or within synaptic transmission involved in micturition	IGI IGI: Inferred from genetic interaction	10531434	MGI
acts upstream of or within vestibulocochlear nerve development	IMP IMP: Inferred from mutant phenotype	15788760	MGI
acts upstream of or within visual learning	IMP IMP: Inferred from mutant phenotype	10064590	MGI
acts upstream of or within visual perception	IMP IMP: Inferred from mutant phenotype	11344259	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of acetylcholine-gated channel complex	IDA IDA: Inferred from direct assay	12944511	MGI
is active in cholinergic synapse	IDA IDA: Inferred from direct assay	12079404	MGI
is active in cholinergic synapse	IMP IMP: Inferred from mutant phenotype	23811311	MGI
is active in dopaminergic synapse	IDA IDA: Inferred from direct assay	11145999	MGI
is active in dopaminergic synapse	IMP IMP: Inferred from mutant phenotype	11145999	MGI
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	15963492	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	15741168	MGI
is active in postsynaptic specialization membrane	IDA IDA: Inferred from direct assay	12079404	MGI
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	24607281	MGI
is active in presynaptic membrane	IEP IEP: Inferred from expression pattern	24607281	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

neuronal acetylcholine receptor subunit beta-2

acetylcholine receptor beta 2 neural

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02675	CHRNB2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Chrnb2	NCBI	NCBI:1141

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