Chrnb2 - cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal) Gene

Also Known as Acrb2; Acrb-2; [b]2-nAchR; C030030P04Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11444

Summary

Enables acetylcholine-gated cation-selective channel activity. Involved in regulation of synaptic vesicle exocytosis. Acts upstream of or within several processes, including learning or memory; nervous system development; and regulation of circadian sleep/wake cycle, sleep. Located in external side of plasma membrane. Is integral component of postsynaptic specialization membrane and integral component of presynaptic membrane. Part of acetylcholine-gated channel complex. Is active in cholinergic synapse and dopaminergic synapse. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Used to study attention deficit hyperactivity disorder; autism spectrum disorder; and autosomal dominant nocturnal frontal lobe epilepsy 3. Human ortholog(s) of this gene implicated in autosomal dominant nocturnal frontal lobe epilepsy and autosomal dominant nocturnal frontal lobe epilepsy 3. Orthologous to human CHRNB2 (cholinergic receptor nicotinic beta 2 subunit). [provided by Alliance of Genome Resources, Apr 2022]

Chrnb2 Products (1)

mRNA Protein Name
NM_009602.4 NP_033732.2 neuronal acetylcholine receptor subunit beta-2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables acetylcholine-gated monoatomic cation-selective channel activity IDA
IDA: Inferred from direct assay
9614223 MGI
enables acetylcholine-gated monoatomic cation-selective channel activity IGI
IGI: Inferred from genetic interaction
15569257 MGI
enables acetylcholine-gated monoatomic cation-selective channel activity IMP
IMP: Inferred from mutant phenotype
11222635 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12944511 MGI
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IDA
IDA: Inferred from direct assay
23811311 MGI
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IMP
IMP: Inferred from mutant phenotype
23811311 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within B cell activation IMP
IMP: Inferred from mutant phenotype
15963492 MGI
acts upstream of B cell proliferation IGI
IGI: Inferred from genetic interaction
15963492 MGI
acts upstream of or within acetylcholine receptor signaling pathway IDA
IDA: Inferred from direct assay
26276394 MGI
acts upstream of action potential IMP
IMP: Inferred from mutant phenotype
15456819 MGI
acts upstream of or within associative learning IGI
IGI: Inferred from genetic interaction
15541879 MGI
acts upstream of or within behavioral response to nicotine IMP
IMP: Inferred from mutant phenotype
11955523 MGI
acts upstream of or within calcium ion transport IGI
IGI: Inferred from genetic interaction
15569257 MGI
acts upstream of or within central nervous system neuron axonogenesis IMP
IMP: Inferred from mutant phenotype
12097474 MGI
acts upstream of or within central nervous system projection neuron axonogenesis IMP
IMP: Inferred from mutant phenotype
11344259 MGI
acts upstream of or within conditioned taste aversion IMP
IMP: Inferred from mutant phenotype
11955523 MGI
acts upstream of dopamine secretion IMP
IMP: Inferred from mutant phenotype
9428762 MGI
acts upstream of establishment of localization in cell IMP
IMP: Inferred from mutant phenotype
9428762 MGI
acts upstream of or within lateral geniculate nucleus development IMP
IMP: Inferred from mutant phenotype
12097474 MGI
acts upstream of or within learning IMP
IMP: Inferred from mutant phenotype
11044747 MGI
acts upstream of or within locomotory behavior IMP
IMP: Inferred from mutant phenotype
9428762 MGI
acts upstream of or within membrane depolarization IMP
IMP: Inferred from mutant phenotype
11222635 MGI
acts upstream of or within memory IMP
IMP: Inferred from mutant phenotype
7870173 MGI
acts upstream of or within negative regulation of neuronal action potential IMP
IMP: Inferred from mutant phenotype
15456819 MGI
acts upstream of or within neuronal action potential IGI
IGI: Inferred from genetic interaction
10531434 MGI
acts upstream of neuronal action potential IMP
IMP: Inferred from mutant phenotype
15456819 MGI
acts upstream of or within neuronal action potential IMP
IMP: Inferred from mutant phenotype
10235262 MGI
acts upstream of or within optic nerve morphogenesis IMP
IMP: Inferred from mutant phenotype
11344259 MGI
acts upstream of or within positive regulation of B cell proliferation IGI
IGI: Inferred from genetic interaction
15963492 MGI
acts upstream of or within positive regulation of dopamine secretion IMP
IMP: Inferred from mutant phenotype
9428762 MGI
acts upstream of or within positive regulation of synaptic transmission, dopaminergic IMP
IMP: Inferred from mutant phenotype
15464132 MGI
involved in presynaptic modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
11145999 MGI
involved in presynaptic modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
11145999 MGI
acts upstream of or within regulation of circadian sleep/wake cycle, REM sleep IMP
IMP: Inferred from mutant phenotype
15215293 MGI
acts upstream of or within regulation of circadian sleep/wake cycle, non-REM sleep IMP
IMP: Inferred from mutant phenotype
15215293 MGI
acts upstream of or within regulation of dendrite morphogenesis IMP
IMP: Inferred from mutant phenotype
11027228 MGI
acts upstream of or within regulation of dopamine metabolic process IMP
IMP: Inferred from mutant phenotype
11282258 MGI
acts upstream of or within regulation of dopamine secretion IMP
IMP: Inferred from mutant phenotype
12944511 MGI
acts upstream of or within regulation of membrane potential IGI
IGI: Inferred from genetic interaction
10531434 MGI
acts upstream of or within regulation of membrane potential IMP
IMP: Inferred from mutant phenotype
9428762 MGI
acts upstream of or within regulation of synapse assembly IMP
IMP: Inferred from mutant phenotype
17301182 MGI
acts upstream of or within regulation of synaptic transmission, dopaminergic IMP
IMP: Inferred from mutant phenotype
16772172 MGI
acts upstream of or within response to cocaine IMP
IMP: Inferred from mutant phenotype
11282258 MGI
acts upstream of or within response to ethanol IMP
IMP: Inferred from mutant phenotype
15489024 MGI
acts upstream of or within response to hypoxia IMP
IMP: Inferred from mutant phenotype
15450117 MGI
acts upstream of or within response to nicotine IGI
IGI: Inferred from genetic interaction
10531434 MGI
acts upstream of or within response to nicotine IMP
IMP: Inferred from mutant phenotype
9428762 MGI
acts upstream of or within sensory perception of pain IMP
IMP: Inferred from mutant phenotype
10235262 MGI
acts upstream of or within sensory perception of sound IMP
IMP: Inferred from mutant phenotype
15788760 MGI
acts upstream of or within smooth muscle contraction IGI
IGI: Inferred from genetic interaction
10531434 MGI
acts upstream of or within social behavior IMP
IMP: Inferred from mutant phenotype
12876201 MGI
acts upstream of or within synaptic transmission involved in micturition IGI
IGI: Inferred from genetic interaction
10531434 MGI
acts upstream of or within vestibulocochlear nerve development IMP
IMP: Inferred from mutant phenotype
15788760 MGI
acts upstream of or within visual learning IMP
IMP: Inferred from mutant phenotype
10064590 MGI
acts upstream of or within visual perception IMP
IMP: Inferred from mutant phenotype
11344259 MGI
Cellular Component GO Annotation Evidence References Source
part of acetylcholine-gated channel complex IDA
IDA: Inferred from direct assay
12944511 MGI
is active in cholinergic synapse IDA
IDA: Inferred from direct assay
12079404 MGI
is active in cholinergic synapse IMP
IMP: Inferred from mutant phenotype
23811311 MGI
is active in dopaminergic synapse IDA
IDA: Inferred from direct assay
11145999 MGI
is active in dopaminergic synapse IMP
IMP: Inferred from mutant phenotype
11145999 MGI
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
15963492 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
15741168 MGI
is active in postsynaptic specialization membrane IDA
IDA: Inferred from direct assay
12079404 MGI
is active in presynaptic membrane IDA
IDA: Inferred from direct assay
24607281 MGI
is active in presynaptic membrane IEP
IEP: Inferred from expression pattern
24607281 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neuronal acetylcholine receptor subunit beta-2

  • acetylcholine receptor beta 2 neural

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02675 CHRNB2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Chrnb2 NCBI NCBI:1141