Arhgef7 - Rho guanine nucleotide exchange factor 7 Gene

Also Known as P85spr; Pak3bp

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 114559

Summary

Enables protein kinase binding activity. Contributes to small GTPase binding activity. Involved in actin Cytoskeleton organization; astrocyte cell migration; and small GTPase mediated signal transduction. Located in cytoplasm; focal adhesion; and growth cone. Part of protein-containing complex. Is active in GABA-ergic synapse. Orthologous to human ARHGEF7 (Rho guanine nucleotide exchange factor 7). [provided by Alliance of Genome Resources, Apr 2022]

Arhgef7 Products (3)

mRNA Protein Name
NM_001113521.2 NP_001106993.2 rho guanine nucleotide exchange factor 7 isoform a
NM_001113522.2 NP_001106994.2 rho guanine nucleotide exchange factor 7 isoform b
NM_053740.3 NP_446192.3 rho guanine nucleotide exchange factor 7 isoform c

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12473661 RGD
enables protein kinase binding IPI
IPI: Inferred from physical interaction
16527308 RGD
contributes to small GTPase binding IPI
IPI: Inferred from physical interaction
11950598 RGD
Biological Process GO Annotation Evidence References Source
involved in astrocyte cell migration IMP
IMP: Inferred from mutant phenotype
17081755 RGD
involved in postsynaptic actin cytoskeleton organization IDA
IDA: Inferred from direct assay
25284783 RGD
involved in postsynaptic actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
25284783 RGD
involved in presynaptic actin cytoskeleton organization IDA
IDA: Inferred from direct assay
22114281 RGD
involved in presynaptic actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
22114281 RGD
involved in small GTPase-mediated signal transduction IDA
IDA: Inferred from direct assay
12226077 RGD
Cellular Component GO Annotation Evidence References Source
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
25284783 RGD
is active in GABA-ergic synapse IMP
IMP: Inferred from mutant phenotype
25284783 RGD
located in focal adhesion IDA
IDA: Inferred from direct assay
17081755 RGD
located in growth cone IDA
IDA: Inferred from direct assay
12226077 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
11950598 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

rho guanine nucleotide exchange factor 7

  • PAK-interacting exchange factor beta

  • Rho guanine nucleotide exchange factor (GEF) 7

  • beta-Pix

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00964 ARHGEF7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21987 Arhgef7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Arhgef7 NCBI NCBI:8874