Arhgef7 - Rho guanine nucleotide exchange factor 7 Gene

Rattus norvegicus

Also known as P85spr; Pak3bp

Gene ID: 114559 | Gene type: protein coding

About Arhgef7

Summary

Enables protein kinase binding activity. Contributes to small GTPase binding activity. Involved in actin Cytoskeleton organization; astrocyte cell migration; and small GTPase mediated signal transduction. Located in cytoplasm; focal adhesion; and growth cone. Part of protein-containing complex. Is active in GABA-ergic synapse. Orthologous to human ARHGEF7 (Rho guanine nucleotide exchange factor 7). [provided by Alliance of Genome Resources, Apr 2022]

Arhgef7 Products(3)

mRNA	Protein	Name
NM_001113521.2	NP_001106993.2	rho guanine nucleotide exchange factor 7 isoform a
NM_001113522.2	NP_001106994.2	rho guanine nucleotide exchange factor 7 isoform b
NM_053740.3	NP_446192.3	rho guanine nucleotide exchange factor 7 isoform c

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12473661	RGD
enables protein kinase binding	IPI IPI: Inferred from physical interaction	16527308	RGD
contributes to small GTPase binding	IPI IPI: Inferred from physical interaction	11950598	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in astrocyte cell migration	IMP IMP: Inferred from mutant phenotype	17081755	RGD
involved in postsynaptic actin cytoskeleton organization	IDA IDA: Inferred from direct assay	25284783	RGD
involved in postsynaptic actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	25284783	RGD
involved in presynaptic actin cytoskeleton organization	IDA IDA: Inferred from direct assay	22114281	RGD
involved in presynaptic actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	22114281	RGD
involved in small GTPase-mediated signal transduction	IDA IDA: Inferred from direct assay	12226077	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
is active in GABA-ergic synapse	IDA IDA: Inferred from direct assay	25284783	RGD
is active in GABA-ergic synapse	IMP IMP: Inferred from mutant phenotype	25284783	RGD
located in focal adhesion	IDA IDA: Inferred from direct assay	17081755	RGD
located in growth cone	IDA IDA: Inferred from direct assay	12226077	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	11950598	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

rho guanine nucleotide exchange factor 7

PAK-interacting exchange factor beta	Rho guanine nucleotide exchange factor (GEF) 7
beta-Pix

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00964	ARHGEF7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21987	Arhgef7 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Arhgef7	NCBI	NCBI:8874

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