Tle6 - transducin-like enhancer of split 6 Gene

Also Known as Grg6; 1810057E06Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 114606

Summary

Predicted to enable transcription corepressor activity. Involved in several processes, including Cytoskeleton organization; positive regulation of embryonic development; and spermatogonial cell division. Acts upstream of or within positive regulation of neurogenesis and positive regulation of neuron differentiation. Located in cell cortex and nucleus. Part of subcortical maternal complex. Is expressed in several structures, including brain; early conceptus; foregut-midgut junction; gonad; and metanephric mesenchyme. Human ortholog(s) of this gene implicated in infertility. Orthologous to human TLE6 (TLE family member 6, subcortical maternal complex member). [provided by Alliance of Genome Resources, Apr 2022]

Tle6 Products (4)

mRNA Protein Name
NM_001346695.1 NP_001333624.1 transducin-like enhancer protein 6 isoform 2
NM_001359134.1 NP_001346063.1 transducin-like enhancer protein 6 isoform 3
NM_001359135.1 NP_001346064.1 transducin-like enhancer protein 6 isoform 3
NM_053254.2 NP_444484.1 transducin-like enhancer protein 6 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16314515 MGI
Biological Process GO Annotation Evidence References Source
involved in actin filament organization IMP
IMP: Inferred from mutant phenotype
25208553 MGI
involved in endoplasmic reticulum localization IMP
IMP: Inferred from mutant phenotype
28992324 MGI
involved in establishment of spindle localization IMP
IMP: Inferred from mutant phenotype
25208553 MGI
involved in mitochondrion localization IMP
IMP: Inferred from mutant phenotype
28992324 MGI
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
23990468 MGI
involved in positive regulation of embryonic development IMP
IMP: Inferred from mutant phenotype
25208553 MGI
acts upstream of or within positive regulation of neurogenesis IMP
IMP: Inferred from mutant phenotype
16314515 MGI
acts upstream of or within positive regulation of neuron differentiation IGI
IGI: Inferred from genetic interaction
16314515 MGI
involved in regulation of cell division IMP
IMP: Inferred from mutant phenotype
25208553 MGI
involved in spermatogonial cell division IMP
IMP: Inferred from mutant phenotype
32823735 MGI
Cellular Component GO Annotation Evidence References Source
located in cell cortex IDA
IDA: Inferred from direct assay
18804437 MGI
located in nucleus IDA
IDA: Inferred from direct assay
16314515 MGI
part of subcortical maternal complex IDA
IDA: Inferred from direct assay
18804437 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transducin-like enhancer protein 6

  • Groucho-related protein 6

  • transducin-like enhancer of split 6, homolog of Drosophila E(spl)

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14568 TLE6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tle6 NCBI NCBI:79816