Actg1 - actin, gamma, cytoplasmic 1 Gene

Mus musculus

Also known as E51; Actg; Actl

Gene ID: 11465 | Gene type: protein coding

About Actg1

Summary

Actins are highly conserved proteins that are involved in various types of cell motility and maintenance of the Cytoskeleton. In vertebrates, three main groups of actin isoforms, alpha, beta, and gamma, have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the Cytoskeleton, and as mediators of internal cell motility. Actin, gamma 1, encoded by this gene, is a cytoplasmic actin found in non-muscle cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Actg1 Products(2)

mRNA	Protein	Name
NM_001313923.1	NP_001300852.1	actin, cytoplasmic 2 isoform 2
NM_009609.3	NP_033739.1	actin, cytoplasmic 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19423573	MGI
enables structural constituent of cytoskeleton	IDA IDA: Inferred from direct assay	15194427	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cellular response to type II interferon	IDA IDA: Inferred from direct assay	19144319	MGI
involved in regulation of synaptic vesicle endocytosis	IDA IDA: Inferred from direct assay	27840001	MGI
involved in regulation of synaptic vesicle endocytosis	IMP IMP: Inferred from mutant phenotype	27840001	MGI
acts upstream of or within sarcomere organization	IDA IDA: Inferred from direct assay	15194427	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	27840001	MGI
is active in Schaffer collateral - CA1 synapse	IMP IMP: Inferred from mutant phenotype	27840001	MGI
located in actin cytoskeleton	IDA IDA: Inferred from direct assay	15194427	MGI
located in apical part of cell	IDA IDA: Inferred from direct assay	29891944	MGI
located in basal body patch	IDA IDA: Inferred from direct assay	29891944	MGI
is active in calyx of Held	IDA IDA: Inferred from direct assay	27840001	MGI
is active in calyx of Held	IMP IMP: Inferred from mutant phenotype	27840001	MGI
part of filamentous actin	IDA IDA: Inferred from direct assay	18796539	MGI
located in myofibril	IDA IDA: Inferred from direct assay	15194427	MGI
located in phagocytic vesicle	IDA IDA: Inferred from direct assay	19144319	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

actin, cytoplasmic 2

beta-actin FE-3

gamma-actin

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00218	ACTG1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29451	Actg1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Actg1	NCBI	NCBI:71

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