Rgs14 - regulator of G-protein signaling 14 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 114705

Summary

Enables several functions, including G-protein alpha-subunit binding activity; GTPase regulator activity; and signaling receptor complex adaptor activity. Involved in several processes, including platelet-derived growth factor receptor signaling pathway; regulation of signal transduction; and visual learning. Located in several cellular components, including dendrite; microtubule cytoskeleton; and nucleus. Human ortholog(s) of this gene implicated in nephrolithiasis. Orthologous to human RGS14 (regulator of G protein signaling 14). [provided by Alliance of Genome Resources, Apr 2022]

Rgs14 Products (1)

mRNA Protein Name
NM_053764.2 NP_446216.1 regulator of G-protein signaling 14

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables G-protein alpha-subunit binding IPI
IPI: Inferred from physical interaction
11387333 RGD
enables GDP-dissociation inhibitor activity IDA
IDA: Inferred from direct assay
15337739 RGD
enables GTPase activator activity IDA
IDA: Inferred from direct assay
15337739 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
11387333 RGD
enables protein kinase binding IPI
IPI: Inferred from physical interaction
19878719 RGD
enables signaling receptor complex adaptor activity IDA
IDA: Inferred from direct assay
19319189 RGD
Biological Process GO Annotation Evidence References Source
involved in negative regulation of ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
19878719 RGD
involved in nucleocytoplasmic transport IDA
IDA: Inferred from direct assay
16870394 RGD
involved in platelet-derived growth factor receptor signaling pathway IDA
IDA: Inferred from direct assay
19878719 RGD
involved in positive regulation of neurogenesis IMP
IMP: Inferred from mutant phenotype
19319189 RGD
involved in regulation of G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
11976690 RGD
involved in response to oxidative stress IMP
IMP: Inferred from mutant phenotype
21255223 RGD
involved in visual learning IMP
IMP: Inferred from mutant phenotype
19574389 RGD
Cellular Component GO Annotation Evidence References Source
located in centrosome IDA
IDA: Inferred from direct assay
16870394 RGD
located in cytoplasm IDA
IDA: Inferred from direct assay
16870394 RGD
located in dendrite IDA
IDA: Inferred from direct assay
16819986 RGD
located in nucleus IDA
IDA: Inferred from direct assay
16870394 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
16870394 RGD
located in spindle pole IDA
IDA: Inferred from direct assay
16870394 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

regulator of G-protein signaling 14

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-175763 Z55660043 Inhibitor / Unkown
HY-RS11907 RGS14 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11909 Rgs16 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rgs14 NCBI NCBI:10636