Rgs14 - regulator of G-protein signaling 14 Gene

Rattus norvegicus

Gene ID: 114705 | Gene type: protein coding

About Rgs14

Summary

Enables several functions, including G-protein alpha-subunit binding activity; GTPase regulator activity; and signaling receptor complex adaptor activity. Involved in several processes, including platelet-derived growth factor receptor signaling pathway; regulation of signal transduction; and visual learning. Located in several cellular components, including dendrite; microtubule cytoskeleton; and nucleus. Human ortholog(s) of this gene implicated in nephrolithiasis. Orthologous to human RGS14 (regulator of G protein signaling 14). [provided by Alliance of Genome Resources, Apr 2022]

Rgs14 Products(1)

mRNA	Protein	Name
NM_053764.2	NP_446216.1	regulator of G-protein signaling 14

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables G-protein alpha-subunit binding	IPI IPI: Inferred from physical interaction	11387333	RGD
enables GDP-dissociation inhibitor activity	IDA IDA: Inferred from direct assay	15337739	RGD
enables GTPase activator activity	IDA IDA: Inferred from direct assay	15337739	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	11387333	RGD
enables protein kinase binding	IPI IPI: Inferred from physical interaction	19878719	RGD
enables signaling receptor complex adaptor activity	IDA IDA: Inferred from direct assay	19319189	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	19878719	RGD
involved in nucleocytoplasmic transport	IDA IDA: Inferred from direct assay	16870394	RGD
involved in platelet-derived growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	19878719	RGD
involved in positive regulation of neurogenesis	IMP IMP: Inferred from mutant phenotype	19319189	RGD
involved in regulation of G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	11976690	RGD
involved in response to oxidative stress	IMP IMP: Inferred from mutant phenotype	21255223	RGD
involved in visual learning	IMP IMP: Inferred from mutant phenotype	19574389	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in centrosome	IDA IDA: Inferred from direct assay	16870394	RGD
located in cytoplasm	IDA IDA: Inferred from direct assay	16870394	RGD
located in dendrite	IDA IDA: Inferred from direct assay	16819986	RGD
located in nucleus	IDA IDA: Inferred from direct assay	16870394	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	16870394	RGD
located in spindle pole	IDA IDA: Inferred from direct assay	16870394	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

regulator of G-protein signaling 14

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-175763	Z55660043	Inhibitor	/	Unkown
HY-RS11907	RGS14 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS11909	Rgs16 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rgs14	NCBI	NCBI:10636

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