Spred1 - sprouty protein with EVH-1 domain 1, related sequence Gene

Also Known as 5730461F13Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 114715

Summary

This gene encodes a membrane-associated protein that is phosphorylated by tyrosine kinases in response to growth factors. The encoded protein acts as a negative regulator of the mitogen-activated protein (MAP) kinase signaling pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]

Spred1 Products (2)

mRNA	Protein	Name
NM_001277256.2	NP_001264185.1	sprouty-related, EVH1 domain-containing protein 1 isoform 2
NM_033524.4	NP_277059.1	sprouty-related, EVH1 domain-containing protein 1 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12646235	MGI
enables protein kinase binding	IPI IPI: Inferred from physical interaction	20736167	MGI
enables protein serine/threonine kinase inhibitor activity	IDA IDA: Inferred from direct assay	20736167	MGI
enables stem cell factor receptor binding	IPI IPI: Inferred from physical interaction	12646235	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	26934179	MGI
acts upstream of or within negative regulation of MAPK cascade	IMP IMP: Inferred from mutant phenotype	12646235	MGI
involved in negative regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	26934179	MGI
involved in negative regulation of cell migration involved in sprouting angiogenesis	IDA IDA: Inferred from direct assay	18694565	MGI
involved in negative regulation of epithelial to mesenchymal transition	IDA IDA: Inferred from direct assay	25576668	MGI
involved in negative regulation of lens fiber cell differentiation	IDA IDA: Inferred from direct assay	29501879	MGI
involved in negative regulation of peptidyl-threonine phosphorylation	IDA IDA: Inferred from direct assay	20736167	MGI
involved in negative regulation of transforming growth factor beta receptor signaling pathway	IDA IDA: Inferred from direct assay	25576668	MGI
involved in positive regulation of DNA damage response, signal transduction by p53 class mediator	IDA IDA: Inferred from direct assay	20736167	MGI
involved in regulation of protein deacetylation	IDA IDA: Inferred from direct assay	20736167	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
sprouty-related, EVH1 domain-containing protein 1	sprouty-related protein 1 with EVH-1 domain

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13709	SPRED1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Spred1	NCBI	NCBI:161742