Spred1 - sprouty protein with EVH-1 domain 1, related sequence Gene

Also Known as 5730461F13Rik

生物種: Mus musculus

遺伝子タイプ: protein coding
遺伝子ID: 114715

Summary

This gene encodes a membrane-associated protein that is phosphorylated by tyrosine Kinases in response to growth factors. The encoded protein acts as a negative regulator of the mitogen-activated protein (MAP) kinase signaling pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]

Spred1 Products (2)

mRNA Protein Name
NM_001277256.2 NP_001264185.1 sprouty-related, EVH1 domain-containing protein 1 isoform 2
NM_033524.4 NP_277059.1 sprouty-related, EVH1 domain-containing protein 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
12646235 MGI
enables protein kinase binding IPI
IPI: Inferred from physical interaction
20736167 MGI
enables protein serine/threonine kinase inhibitor activity IDA
IDA: Inferred from direct assay
20736167 MGI
enables stem cell factor receptor binding IPI
IPI: Inferred from physical interaction
12646235 MGI
Biological Process GO Annotation Evidence 参考文献 由来
involved in negative regulation of ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
26934179 MGI
acts upstream of or within negative regulation of MAPK cascade IMP
IMP: Inferred from mutant phenotype
12646235 MGI
involved in negative regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
26934179 MGI
involved in negative regulation of cell migration involved in sprouting angiogenesis IDA
IDA: Inferred from direct assay
18694565 MGI
involved in negative regulation of epithelial to mesenchymal transition IDA
IDA: Inferred from direct assay
25576668 MGI
involved in negative regulation of lens fiber cell differentiation IDA
IDA: Inferred from direct assay
29501879 MGI
involved in negative regulation of peptidyl-threonine phosphorylation IDA
IDA: Inferred from direct assay
20736167 MGI
involved in negative regulation of transforming growth factor beta receptor signaling pathway IDA
IDA: Inferred from direct assay
25576668 MGI
involved in positive regulation of DNA damage response, signal transduction by p53 class mediator IDA
IDA: Inferred from direct assay
20736167 MGI
involved in regulation of protein deacetylation IDA
IDA: Inferred from direct assay
20736167 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sprouty-related, EVH1 domain-containing protein 1

  • sprouty-related protein 1 with EVH-1 domain

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS13709 SPRED1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Homo sapiens Spred1 NCBI NCBI:161742