Actn3 - actinin alpha 3 Gene

Mus musculus

Gene ID: 11474 | Gene type: protein coding

About Actn3

Summary

This gene encodes a member of the alpha-actin binding protein gene family. The encoded protein is primarily expressed in skeletal muscle and functions as a structural component of sarcomeric Z line. This protein is involved in crosslinking actin containing thin filaments. [provided by RefSeq, Sep 2015]

Actn3 Products(1)

mRNA	Protein	Name
NM_013456.2	NP_038484.1	alpha-actinin-3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables actin filament binding	IDA IDA: Inferred from direct assay	15465019	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11114196	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in bone morphogenesis	IMP IMP: Inferred from mutant phenotype	21784188	MGI
involved in negative regulation of calcineurin-NFAT signaling cascade	IMP IMP: Inferred from mutant phenotype	24234654	MGI
involved in negative regulation of cold-induced thermogenesis	IMP IMP: Inferred from mutant phenotype	25590636	MGI
involved in negative regulation of glycolytic process	IMP IMP: Inferred from mutant phenotype	17828264	MGI
involved in negative regulation of oxidative phosphorylation	IMP IMP: Inferred from mutant phenotype	18178581	MGI
involved in negative regulation of relaxation of muscle	IMP IMP: Inferred from mutant phenotype	18178581	MGI
NOT involved in osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	21784188	MGI
involved in positive regulation of bone mineralization involved in bone maturation	IMP IMP: Inferred from mutant phenotype	21784188	MGI
involved in positive regulation of fast-twitch skeletal muscle fiber contraction	IMP IMP: Inferred from mutant phenotype	18178581	MGI
involved in positive regulation of glucose catabolic process to lactate via pyruvate	IMP IMP: Inferred from mutant phenotype	17828264	MGI
involved in positive regulation of skeletal muscle fiber development	IMP IMP: Inferred from mutant phenotype	18178581	MGI
involved in positive regulation of skeletal muscle tissue growth	IMP IMP: Inferred from mutant phenotype	18178581	MGI
involved in regulation of aerobic respiration	IMP IMP: Inferred from mutant phenotype	17828264	MGI
involved in regulation of muscle system process	IMP IMP: Inferred from mutant phenotype	18178581	MGI
involved in regulation of the force of skeletal muscle contraction	IMP IMP: Inferred from mutant phenotype	17828264	MGI
involved in response to denervation involved in regulation of muscle adaptation	IMP IMP: Inferred from mutant phenotype	24234654	MGI
involved in skeletal muscle atrophy	IMP IMP: Inferred from mutant phenotype	24234654	MGI
involved in transition between fast and slow fiber	IMP IMP: Inferred from mutant phenotype	17828264	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in Z disc	IDA IDA: Inferred from direct assay	20215401	MGI
located in brush border	IDA IDA: Inferred from direct assay	22114352	MGI
located in sarcomere	IDA IDA: Inferred from direct assay	16585392	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

alpha-actinin-3

F-actin cross-linking protein

alpha-actinin skeletal muscle

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00225	ACTN3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Actn3	NCBI	NCBI:89

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