XKR4 - XK related 4 Gene

Also Known as XRG4; hXKR4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 114786

About XKR4

This gene has 3 transcripts (splice variants), 200 orthologues and 5 paralogues. Biased expression in brain (RPKM 2.2), colon (RPKM 0.4) and 8 other tissues.

Summary

Enables phospholipid scramblase activity. Involved in phosphatidylserine exposure on apoptotic cell surface. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

XKR4 Products (1)

mRNA	Protein	Name
NM_052898.2	NP_443130.1	XK-related protein 4

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables phospholipid scramblase activity	IDA IDA: Inferred from direct assay	33725486	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	33725486	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in phosphatidylserine exposure on apoptotic cell surface	IDA IDA: Inferred from direct assay	33725486	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

XKR4 Protein Structure

XK-related

0
100
200
300
400
500
600
650 a.a.

Protein Preferred Names	Protein Names
XK-related protein 4	X Kell blood group precursor-related family, member 4

Related Diseases

Diseases	Alias
Lissencephaly 9 With Complex Brainstem Malformation	LIS9 Posterior-Predominant Lissencephaly-Broad Flat Pons And Medulla-Midline Crossing Defects Syndrome
Mcleod Syndrome	Mcleod Neuroacanthocytosis Syndrome MLS X-Linked Mcleod Syndrome Mcleod Phenotype Neuroacanthocytosis, Mcleod Type Mcleod Syndrome With Or Without Chronic Granulomatous Disease MCLDS Mcleod Type Neuroacanthocytosis Mcleod Syndrome With Chronic Granulomatous Disease Neuroacanthocytosis Mcleod Type Blood Group Deletion Syndrome
Neuroacanthocytosis	Neuroacanthocytosis Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15879	XKR4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	XKR4	RGD	RGD:1549780
Felis catus	XKR4	VGNC	VGNC:81674
Macaca mulatta	XKR4	VGNC	VGNC:84136
Bos taurus	XKR4	VGNC	VGNC:36987
Mus musculus	XKR4	MGD	MGI:3528744
Canis familiaris	XKR4	VGNC	VGNC:54125