Add1 - adducin 1 (alpha) Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11518

Summary

A structural constituent of Cytoskeleton. Involved in cellular response to calcium ion; positive regulation of adherens junction organization; and positive regulation of establishment of endothelial barrier. Acts upstream of or within several processes, including cell volume homeostasis; erythrocyte differentiation; and Hemoglobin metabolic process. Located in adherens junction; cytoskeleton; and membrane. Colocalizes with plasma membrane. Is expressed in brown fat; cerebellum; and spleen. Used to study hydrocephalus. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; artery disease (multiple); familial combined hyperlipidemia; and gastroschisis. Orthologous to human ADD1 (adducin 1). [provided by Alliance of Genome Resources, Apr 2022]

Add1 Products (11)

mRNA Protein Name
NM_001024458.4 NP_001019629.2 alpha-adducin isoform 1
NM_001102444.2 NP_001095914.1 alpha-adducin isoform 3
NM_001331080.1 NP_001318009.1 alpha-adducin isoform 1
NM_001331081.1 NP_001318010.1 alpha-adducin isoform 4
NM_001331082.1 NP_001318011.1 alpha-adducin isoform 5
NM_001331083.1 NP_001318012.1 alpha-adducin isoform 6
NM_001331084.1 NP_001318013.1 alpha-adducin isoform 7
NM_001331085.1 NP_001318014.1 alpha-adducin isoform 8
NM_001331086.1 NP_001318015.1 alpha-adducin isoform 9
NM_001331087.1 NP_001318016.1 alpha-adducin isoform 2
NM_013457.4 NP_038485.1 alpha-adducin isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables structural constituent of cytoskeleton IDA
IDA: Inferred from direct assay
10485892 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cell morphogenesis IMP
IMP: Inferred from mutant phenotype
18723693 MGI
acts upstream of or within cell volume homeostasis IMP
IMP: Inferred from mutant phenotype
18723693 MGI
involved in cellular response to calcium ion IDA
IDA: Inferred from direct assay
25978380 MGI
acts upstream of or within erythrocyte differentiation IMP
IMP: Inferred from mutant phenotype
18723693 MGI
acts upstream of or within hemoglobin metabolic process IMP
IMP: Inferred from mutant phenotype
18723693 MGI
acts upstream of or within homeostasis of number of cells within a tissue IMP
IMP: Inferred from mutant phenotype
18723693 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
18723693 MGI
acts upstream of or within multicellular organism growth IMP
IMP: Inferred from mutant phenotype
18723693 MGI
involved in positive regulation of adherens junction organization IMP
IMP: Inferred from mutant phenotype
25978380 MGI
involved in positive regulation of establishment of endothelial barrier IMP
IMP: Inferred from mutant phenotype
25978380 MGI
Cellular Component GO Annotation Evidence References Source
located in adherens junction IMP
IMP: Inferred from mutant phenotype
25978380 MGI
located in cytoskeleton IDA
IDA: Inferred from direct assay
10485892 MGI
located in membrane IDA
IDA: Inferred from direct assay
10485892 MGI
colocalizes with plasma membrane IMP
IMP: Inferred from mutant phenotype
25978380 MGI
is active in synapse EXP
EXP: Inferred from Experiment
34269176 MGI
is active in synapse IDA
IDA: Inferred from direct assay
34269176 MGI
is active in synapse IMP
IMP: Inferred from mutant phenotype
34269176 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

alpha-adducin

  • erythrocyte adducin subunit alpha

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00338 ADD1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17721 Srebf1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24186 Srebf1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Add1 NCBI NCBI:118