Adra1a - adrenergic receptor, alpha 1a Gene

Also Known as Adra1c

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11549

Summary

This gene encodes one of several multipass transmembrane proteins that function as G protein-coupled receptors. The encoded protein binds to epinephrine and norepinephrine to mediate signaling in cells of the cardiac, nervous, and Other organ systems. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012]

Adra1a Products (4)

mRNA Protein Name
NM_001271759.1 NP_001258688.1 alpha-1A adrenergic receptor isoform 2
NM_001271760.1 NP_001258689.1 alpha-1A adrenergic receptor isoform 1
NM_001271761.1 NP_001258690.1 alpha-1A adrenergic receptor isoform 3
NM_013461.4 NP_038489.2 alpha-1A adrenergic receptor isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables alpha1-adrenergic receptor activity IDA
IDA: Inferred from direct assay
9630362 MGI
enables alpha1-adrenergic receptor activity IMP
IMP: Inferred from mutant phenotype
12782680 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of MAPK cascade IGI
IGI: Inferred from genetic interaction
12782680 MGI
acts upstream of or within adult heart development IGI
IGI: Inferred from genetic interaction
12782680 MGI
acts upstream of or within cell growth involved in cardiac muscle cell development IGI
IGI: Inferred from genetic interaction
12782680 MGI
acts upstream of or within negative regulation of autophagy IDA
IDA: Inferred from direct assay
27994061 MGI
acts upstream of or within negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure IMP
IMP: Inferred from mutant phenotype
12093905 MGI
involved in neuron-glial cell signaling IGI
IGI: Inferred from genetic interaction
10493741 MGI
acts upstream of or within norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure IMP
IMP: Inferred from mutant phenotype
12093905 MGI
acts upstream of or within organ growth IGI
IGI: Inferred from genetic interaction
12782680 MGI
involved in pilomotor reflex IDA
IDA: Inferred from direct assay
21335239 MGI
acts upstream of or within positive regulation of MAPK cascade IGI
IGI: Inferred from genetic interaction
12782680 MGI
acts upstream of or within positive regulation of cardiac muscle hypertrophy IDA
IDA: Inferred from direct assay
27994061 MGI
acts upstream of or within positive regulation of heart rate by epinephrine-norepinephrine IGI
IGI: Inferred from genetic interaction
12782680 MGI
acts upstream of or within positive regulation of non-membrane spanning protein tyrosine kinase activity IDA
IDA: Inferred from direct assay
27994061 MGI
involved in positive regulation of smooth muscle contraction IDA
IDA: Inferred from direct assay
21335239 MGI
acts upstream of or within positive regulation of the force of heart contraction by epinephrine-norepinephrine IGI
IGI: Inferred from genetic interaction
12595294 MGI
involved in regulation of blood pressure IMP
IMP: Inferred from mutant phenotype
26531127 MGI
Cellular Component GO Annotation Evidence References Source
located in membrane IDA
IDA: Inferred from direct assay
9630362 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

alpha-1A adrenergic receptor

  • alpha-1A adrenoceptor

  • alpha-1A adrenoreceptor

  • alpha-1C adrenergic receptor

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00408 ADRA1A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00410 ADRA1D Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21088 Adra1a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27606 Adra1a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Adra1a NCBI NCBI:148