Agtr1a - angiotensin II receptor, type 1a Gene

Also Known as AT1; AG2S; AT1a; AT2R1; Agtr1; AT2R1A; Agt1ar; Agtr-1a; Angtr-1a; 1810074K20Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11607

Summary

Enables angiotensin type I receptor activity. Involved in multicellular organism aging; positive regulation of cytokine production; and regulation of blood pressure. Acts upstream of or within several processes, including circulatory system development; negative regulation of smooth muscle cell apoptotic process; and regulation of blood pressure. Located in endosome and plasma membrane. Is expressed in several structures, including central nervous system; endocrine gland; extraembryonic component; genitourinary system; and submandibular gland. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; COVID-19; artery disease (multiple); chronic kidney disease; and sarcoidosis. Orthologous to human AGTR1 (angiotensin II receptor type 1). [provided by Alliance of Genome Resources, Apr 2022]

Agtr1a Products (1)

mRNA Protein Name
NM_177322.3 NP_796296.1 type-1 angiotensin II receptor A

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables angiotensin type I receptor activity IDA
IDA: Inferred from direct assay
12657564 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10358057 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within blood vessel development IGI
IGI: Inferred from genetic interaction
9466969 MGI
acts upstream of or within brain renin-angiotensin system IMP
IMP: Inferred from mutant phenotype
10880053 MGI
acts upstream of or within drinking behavior IGI
IGI: Inferred from genetic interaction
10880053 MGI
acts upstream of or within drinking behavior IMP
IMP: Inferred from mutant phenotype
10880053 MGI
involved in gene expression IMP
IMP: Inferred from mutant phenotype
24206662 MGI
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
16585392 MGI
acts upstream of or within inflammatory response IGI
IGI: Inferred from genetic interaction
19404405 MGI
acts upstream of or within kidney development IGI
IGI: Inferred from genetic interaction
9466969 MGI
acts upstream of or within kidney development IMP
IMP: Inferred from mutant phenotype
12167595 MGI
NOT acts upstream of or within negative regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
9310306 MGI
acts upstream of or within negative regulation of smooth muscle cell apoptotic process IMP
IMP: Inferred from mutant phenotype
19508861 MGI
acts upstream of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
9310306 MGI
acts upstream of or within positive regulation of blood pressure IDA
IDA: Inferred from direct assay
12486173 MGI
acts upstream of or within positive regulation of blood pressure IGI
IGI: Inferred from genetic interaction
9691085 MGI
acts upstream of or within positive regulation of blood pressure IMP
IMP: Inferred from mutant phenotype
12486173 MGI
involved in positive regulation of cytokine production IMP
IMP: Inferred from mutant phenotype
19023134 MGI
acts upstream of or within positive regulation of vascular associated smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
19508861 MGI
involved in regulation of blood pressure IMP
IMP: Inferred from mutant phenotype
26531127 MGI
acts upstream of or within regulation of renal output by angiotensin IMP
IMP: Inferred from mutant phenotype
12167595 MGI
acts upstream of or within regulation of systemic arterial blood pressure by circulatory renin-angiotensin IGI
IGI: Inferred from genetic interaction
9466969 MGI
acts upstream of or within regulation of vascular associated smooth muscle cell apoptotic process IGI
IGI: Inferred from genetic interaction
19508861 MGI
acts upstream of or within renin secretion into blood stream IMP
IMP: Inferred from mutant phenotype
12167595 MGI
acts upstream of or within renin-angiotensin regulation of aldosterone production IMP
IMP: Inferred from mutant phenotype
12167595 MGI
acts upstream of vascular associated smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
19508861 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
15499027 MGI
located in endosome IDA
IDA: Inferred from direct assay
14718562 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
14718562 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

type-1 angiotensin II receptor A

type-1A angiotensin II receptor

  • AT1 receptor A

  • angiotensin II type-1 receptor A

  • angiotensin II type-1A receptor

  • angiotensin receptor 1

  • angiotensin receptor 1a