Akap4 - A kinase (PRKA) anchor protein 4 Gene

Mus musculus

Also known as p82; Fsc1; PRKA4; AKAP-4; AKAP82; mAKAP82

Gene ID: 11643 | Gene type: protein coding

About Akap4

Summary

Enables protein kinase A binding activity. Involved in flagellated sperm motility. Acts upstream of or within establishment of protein localization; motile cilium assembly; and transmembrane receptor protein serine/threonine kinase signaling pathway. Located in Z disc; perinuclear region of cytoplasm; and sperm flagellum. Orthologous to human AKAP4 (A-kinase anchoring protein 4). [provided by Alliance of Genome Resources, Apr 2022]

Akap4 Products(2)

mRNA	Protein	Name
NM_001042542.2	NP_001036007.1	A-kinase anchor protein 4 isoform b
NM_009651.4	NP_033781.2	A-kinase anchor protein 4 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	9852104	MGI
enables protein kinase A binding	IPI IPI: Inferred from physical interaction	9852104	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cell surface receptor protein serine/threonine kinase signaling pathway	IPI IPI: Inferred from physical interaction	9852104	MGI
acts upstream of or within establishment of localization in cell	IMP IMP: Inferred from mutant phenotype	15385410	MGI
acts upstream of or within establishment of protein localization	IMP IMP: Inferred from mutant phenotype	15385410	MGI
involved in flagellated sperm motility	IMP IMP: Inferred from mutant phenotype	9852104	MGI
acts upstream of or within protein localization	IMP IMP: Inferred from mutant phenotype	8088444	MGI
acts upstream of or within sperm flagellum assembly	IMP IMP: Inferred from mutant phenotype	15385410	MGI
involved in spermatogenesis	IMP IMP: Inferred from mutant phenotype	12167408	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in Z disc	IDA IDA: Inferred from direct assay	17923693	MGI
located in cilium	IDA IDA: Inferred from direct assay	21715716	MGI
located in motile cilium	IDA IDA: Inferred from direct assay	9852104	MGI
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	17923693	MGI
located in sperm fibrous sheath	IDA IDA: Inferred from direct assay	16687649	MGI
located in sperm principal piece	IDA IDA: Inferred from direct assay	12606363	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

A-kinase anchor protein 4

A kinase anchoring protein 4	A-kinase anchor protein 82 kDa
major sperm fibrous sheath protein	protein kinase A-anchoring protein 4

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00519	AKAP4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Akap4	NCBI	NCBI:8852

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