Akap4 - A kinase (PRKA) anchor protein 4 Gene

Also Known as p82; Fsc1; PRKA4; AKAP-4; AKAP82; mAKAP82

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11643

Summary

Enables protein kinase A binding activity. Involved in flagellated sperm motility. Acts upstream of or within establishment of protein localization; motile cilium assembly; and transmembrane receptor protein serine/threonine kinase signaling pathway. Located in Z disc; perinuclear region of cytoplasm; and sperm flagellum. Orthologous to human AKAP4 (A-kinase anchoring protein 4). [provided by Alliance of Genome Resources, Apr 2022]

Akap4 Products (2)

mRNA Protein Name
NM_001042542.2 NP_001036007.1 A-kinase anchor protein 4 isoform b
NM_009651.4 NP_033781.2 A-kinase anchor protein 4 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
9852104 MGI
enables protein kinase A binding IPI
IPI: Inferred from physical interaction
9852104 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cell surface receptor protein serine/threonine kinase signaling pathway IPI
IPI: Inferred from physical interaction
9852104 MGI
acts upstream of or within establishment of localization in cell IMP
IMP: Inferred from mutant phenotype
15385410 MGI
acts upstream of or within establishment of protein localization IMP
IMP: Inferred from mutant phenotype
15385410 MGI
involved in flagellated sperm motility IMP
IMP: Inferred from mutant phenotype
9852104 MGI
acts upstream of or within protein localization IMP
IMP: Inferred from mutant phenotype
8088444 MGI
acts upstream of or within sperm flagellum assembly IMP
IMP: Inferred from mutant phenotype
15385410 MGI
involved in spermatogenesis IMP
IMP: Inferred from mutant phenotype
12167408 MGI
Cellular Component GO Annotation Evidence References Source
located in Z disc IDA
IDA: Inferred from direct assay
17923693 MGI
located in cilium IDA
IDA: Inferred from direct assay
21715716 MGI
located in motile cilium IDA
IDA: Inferred from direct assay
9852104 MGI
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
17923693 MGI
located in sperm fibrous sheath IDA
IDA: Inferred from direct assay
16687649 MGI
located in sperm principal piece IDA
IDA: Inferred from direct assay
12606363 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

A-kinase anchor protein 4

  • A kinase anchoring protein 4

  • A-kinase anchor protein 82 kDa

  • major sperm fibrous sheath protein

  • protein kinase A-anchoring protein 4

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00519 AKAP4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Akap4 NCBI NCBI:8852