2. Gene
  3. Cacnb2 - calcium voltage-gated channel auxiliary subunit beta 2 Gene

Cacnb2 - calcium voltage-gated channel auxiliary subunit beta 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Cacnlb2

Gene ID: 116600 | Gene type: protein coding

About Cacnb2

Summary

Enables several functions, including actin filament binding activity; Calcium Channel regulator activity; and identical protein binding activity. Contributes to voltage-gated Calcium Channel activity. Involved in positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel; positive regulation of high voltage-gated Calcium Channel activity; and protein localization to plasma membrane. Part of L-type voltage-gated Calcium Channel complex. Human ortholog(s) of this gene implicated in Brugada syndrome 4; hypertension; and hypertrophic cardiomyopathy. Orthologous to human CACNB2 (calcium voltage-gated channel auxiliary subunit beta 2). [provided by Alliance of Genome Resources, Apr 2022]

Cacnb2 Products(2)

mRNA Protein Name
NM_001398773.1 NP_001385702.1 voltage-dependent L-type calcium channel subunit beta-2 isoform 1
NM_053851.2 NP_446303.1 voltage-dependent L-type calcium channel subunit beta-2 isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables actin filament binding IDA
IDA: Inferred from direct assay
25533460 RGD
enables calcium channel regulator activity IDA
IDA: Inferred from direct assay
1370480 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
18776052 RGD
enables phosphoprotein binding IPI
IPI: Inferred from physical interaction
19840220 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
24751537 RGD
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
19840220 RGD
enables protein kinase binding IDA
IDA: Inferred from direct assay
18205403 RGD
enables protein kinase binding IPI
IPI: Inferred from physical interaction
19840220 RGD
contributes to voltage-gated calcium channel activity IDA
IDA: Inferred from direct assay
16049183 RGD
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel IDA
IDA: Inferred from direct assay
25533460 RGD
involved in positive regulation of high voltage-gated calcium channel activity IDA
IDA: Inferred from direct assay
25533460 RGD
involved in protein localization to plasma membrane IDA
IDA: Inferred from direct assay
25533460 RGD
involved in regulation of voltage-gated calcium channel activity IDA
IDA: Inferred from direct assay
12042350 RGD
Cellular Component GO Annotation Evidence Reference Source
part of L-type voltage-gated calcium channel complex IDA
IDA: Inferred from direct assay
26680202 RGD
part of voltage-gated calcium channel complex IDA
IDA: Inferred from direct assay
16049183 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

voltage-dependent L-type calcium channel subunit beta-2

CAB2

calcium channel voltage-dependent subunit beta 2

calcium channel, voltage-dependent, beta 2 subunit

voltage-gated calcium channel beta2i subunit

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01806 CACNB2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cacnb2 NCBI NCBI:783