Slc17a7 - solute carrier family 17 member 7 Gene

Rattus norvegicus

Also known as BNPI; Vglut1

Gene ID: 116638 | Gene type: protein coding

About Slc17a7

Summary

Enables inorganic phosphate transmembrane transporter activity and sodium:phosphate symporter activity. Involved in several processes, including neurotransmitter loading into synaptic vesicle; phosphate ion transport; and regulation of synaptic vesicle endocytosis. Located in excitatory synapse and presynaptic active zone. Is integral component of synaptic vesicle membrane. Is active in synaptic vesicle membrane. Biomarker of sciatic neuropathy and transient cerebral ischemia. Orthologous to human SLC17A7 (solute carrier family 17 member 7). [provided by Alliance of Genome Resources, Apr 2022]

Slc17a7 Products(1)

mRNA	Protein	Name
NM_053859.4	NP_446311.1	vesicular glutamate transporter 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables L-glutamate transmembrane transporter activity	IDA IDA: Inferred from direct assay	19169251	RGD
enables L-glutamate uniporter activity	IDA IDA: Inferred from direct assay	10938000	RGD
enables chloride channel activity	IDA IDA: Inferred from direct assay	10938000	RGD
enables phosphate ion uniporter activity	IDA IDA: Inferred from direct assay	29642010	RGD
enables potassium:proton antiporter activity	IDA IDA: Inferred from direct assay	25433636	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	16815333	RGD
enables sodium:phosphate symporter activity	IDA IDA: Inferred from direct assay	29642010	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in L-glutamate transmembrane transport	IDA IDA: Inferred from direct assay	10938000	RGD
involved in chloride transport	IDA IDA: Inferred from direct assay	10938000	RGD
involved in neural retina development	IEP IEP: Inferred from expression pattern	18482716	RGD
involved in phosphate ion homeostasis	IDA IDA: Inferred from direct assay	33440152	RGD
involved in phosphate ion transport	IDA IDA: Inferred from direct assay	8202535	RGD
involved in potassium ion transport	IDA IDA: Inferred from direct assay	25433636	RGD
involved in regulation of synaptic vesicle endocytosis	IMP IMP: Inferred from mutant phenotype	16815333	RGD
involved in sodium-dependent phosphate transport	IDA IDA: Inferred from direct assay	29642010	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in excitatory synapse	IDA IDA: Inferred from direct assay	16519671	RGD
located in presynaptic active zone	IDA IDA: Inferred from direct assay	24613359	RGD
located in synapse	IDA IDA: Inferred from direct assay	15681343	RGD
is active in synaptic vesicle membrane	IDA IDA: Inferred from direct assay	18502731	RGD
located in synaptic vesicle membrane	IDA IDA: Inferred from direct assay	29642010	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

vesicular glutamate transporter 1

brain-specific Na(+)-dependent inorganic phosphate cotransporter	brain-specific Na-dependent inorganic phosphate cotransporter
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7	solute carrier family 17 (vesicular g

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13040	SLC17A7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc17a7	NCBI	NCBI:57030

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