Rims2 - regulating synaptic membrane exocytosis 2 Gene

Also Known as RIM2; Serg2; Rab3ip2; Syt3-rs; Rim2(+4A); mKIAA0751; Rim2(+40A); Rim2(+44A); 2810036I15Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 116838

Summary

Enables transmembrane transporter binding activity. A structural constituent of presynaptic active zone. Involved in neurotransmitter secretion; positive regulation of gene expression; and regulation of nervous system process. Acts upstream of or within several processes, including adenylate cyclase-modulating G protein-coupled receptor signaling pathway; regulation of exocytosis; and signal release. Located in GABA-ergic synapse and inhibitory synapse. Is active in glutamatergic synapse. Is expressed in testis. Orthologous to human RIMS2 (regulating synaptic membrane exocytosis 2). [provided by Alliance of Genome Resources, Apr 2022]

Rims2 Products (4)

mRNA Protein Name
NM_001256382.1 NP_001243311.1 regulating synaptic membrane exocytosis protein 2 isoform a
NM_001256383.1 NP_001243312.1 regulating synaptic membrane exocytosis protein 2 isoform b
NM_001256384.1 NP_001243313.1 regulating synaptic membrane exocytosis protein 2 isoform d
NM_053271.2 NP_444501.1 regulating synaptic membrane exocytosis protein 2 isoform c

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11056535 MGI
enables protein-macromolecule adaptor activity IDA
IDA: Inferred from direct assay
11056535 MGI
enables structural constituent of presynaptic active zone IDA
IDA: Inferred from direct assay
21241895 MGI
enables structural constituent of presynaptic active zone IEP
IEP: Inferred from expression pattern
27537483 MGI
enables structural constituent of presynaptic active zone IMP
IMP: Inferred from mutant phenotype
21241895 MGI
enables transmembrane transporter binding IDA
IDA: Inferred from direct assay
20452978 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within adenylate cyclase-modulating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
11598134 MGI
acts upstream of or within calcium ion-regulated exocytosis of neurotransmitter IGI
IGI: Inferred from genetic interaction
17124501 MGI
acts upstream of or within calcium-ion regulated exocytosis IDA
IDA: Inferred from direct assay
11056535 MGI
involved in establishment of localization in cell IMP
IMP: Inferred from mutant phenotype
11598134 MGI
acts upstream of or within insulin secretion IDA
IDA: Inferred from direct assay
11598134 MGI
involved in insulin secretion IMP
IMP: Inferred from mutant phenotype
11598134 MGI
acts upstream of or within neurotransmitter secretion IGI
IGI: Inferred from genetic interaction
25730884 MGI
involved in positive regulation of excitatory postsynaptic potential IGI
IGI: Inferred from genetic interaction
21262469 MGI
involved in positive regulation of gene expression IGI
IGI: Inferred from genetic interaction
21262469 MGI
involved in positive regulation of inhibitory postsynaptic potential IGI
IGI: Inferred from genetic interaction
21262469 MGI
involved in regulation of calcium-dependent activation of synaptic vesicle fusion IDA
IDA: Inferred from direct assay
21241895 MGI
involved in regulation of calcium-dependent activation of synaptic vesicle fusion IMP
IMP: Inferred from mutant phenotype
21241895 MGI
acts upstream of or within regulation of exocytosis IMP
IMP: Inferred from mutant phenotype
20674857 MGI
acts upstream of or within regulation of membrane potential IDA
IDA: Inferred from direct assay
20452978 MGI
involved in spontaneous neurotransmitter secretion IGI
IGI: Inferred from genetic interaction
21262469 MGI
involved in synaptic vesicle docking IDA
IDA: Inferred from direct assay
21241895 MGI
involved in synaptic vesicle docking IMP
IMP: Inferred from mutant phenotype
21241895 MGI
involved in synaptic vesicle priming IDA
IDA: Inferred from direct assay
21262469 MGI
involved in synaptic vesicle priming IMP
IMP: Inferred from mutant phenotype
21262469 MGI
Cellular Component GO Annotation Evidence References Source
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
21262469 MGI
is active in GABA-ergic synapse IMP
IMP: Inferred from mutant phenotype
21262469 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
21241895 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
21241895 MGI
located in inhibitory synapse IMP
IMP: Inferred from mutant phenotype
22753485 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

regulating synaptic membrane exocytosis protein 2

  • RIM 2

  • Rab3 interacting protein 1

  • Rab3 interacting protein 2

  • rab-3-interacting protein 2

  • rab3-interacting protein 2

  • synaptic exocytosis regulator 2

  • synaptotagmin 3, related sequence

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11979 RIMS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21733 Rims2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28250 Rims2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rims2 NCBI NCBI:9699