Alox12b - arachidonate 12-lipoxygenase, 12R type Gene

Also Known as Aloxe2; e-LOX2; 12R-LOX

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11686

Summary

This gene encodes an enzyme involved in the conversion of arachidonic acid to 12R-hydroxyeicosatetraenoic acid. Mutations in this gene can prevent the formation of the epidermal permeability barrier and cause an ichthyosiform phenotype. [provided by RefSeq, Sep 2015]

Alox12b Products (1)

mRNA Protein Name
NM_009659.2 NP_033789.1 arachidonate 12-lipoxygenase, 12R-type

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables arachidonate 12(S)-lipoxygenase activity IDA
IDA: Inferred from direct assay
10100631 MGI
enables arachidonate 12(S)-lipoxygenase activity IMP
IMP: Inferred from mutant phenotype
11256953 MGI
enables arachidonate 8(R)-lipoxygenase activity IMP
IMP: Inferred from mutant phenotype
11256953 MGI
enables linoleate 9S-lipoxygenase activity IDA
IDA: Inferred from direct assay
16129665 MGI
Biological Process GO Annotation Evidence References Source
involved in arachidonate metabolic process IDA
IDA: Inferred from direct assay
16129665 MGI
involved in arachidonate metabolic process IMP
IMP: Inferred from mutant phenotype
10100631 MGI
NOT involved in bicellular tight junction assembly IMP
IMP: Inferred from mutant phenotype
17403930 MGI
involved in ceramide biosynthetic process IMP
IMP: Inferred from mutant phenotype
17403930 MGI
involved in establishment of skin barrier IMP
IMP: Inferred from mutant phenotype
17403930 MGI
involved in linoleic acid metabolic process IDA
IDA: Inferred from direct assay
16129665 MGI
involved in protein lipidation IMP
IMP: Inferred from mutant phenotype
21558561 MGI
Cellular Component GO Annotation Evidence References Source
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
9837935 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

arachidonate 12-lipoxygenase, 12R-type

  • 12R-lipoxygenase

  • epidermis-type lipoxygenase 12

  • epidermis-type lipoxygenase 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00615 ALOX12B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Alox12b NCBI NCBI:242