Alox12b - arachidonate 12-lipoxygenase, 12R type Gene

Mus musculus

Also known as Aloxe2; e-LOX2; 12R-LOX

Gene ID: 11686 | Gene type: protein coding

About Alox12b

Summary

This gene encodes an enzyme involved in the conversion of arachidonic acid to 12R-hydroxyeicosatetraenoic acid. Mutations in this gene can prevent the formation of the epidermal permeability barrier and cause an ichthyosiform phenotype. [provided by RefSeq, Sep 2015]

Alox12b Products(1)

mRNA	Protein	Name
NM_009659.2	NP_033789.1	arachidonate 12-lipoxygenase, 12R-type

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables arachidonate 12(S)-lipoxygenase activity	IDA IDA: Inferred from direct assay	10100631	MGI
enables arachidonate 12(S)-lipoxygenase activity	IMP IMP: Inferred from mutant phenotype	11256953	MGI
enables arachidonate 8(R)-lipoxygenase activity	IMP IMP: Inferred from mutant phenotype	11256953	MGI
enables linoleate 9S-lipoxygenase activity	IDA IDA: Inferred from direct assay	16129665	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in arachidonate metabolic process	IDA IDA: Inferred from direct assay	16129665	MGI
involved in arachidonate metabolic process	IMP IMP: Inferred from mutant phenotype	10100631	MGI
NOT involved in bicellular tight junction assembly	IMP IMP: Inferred from mutant phenotype	17403930	MGI
involved in ceramide biosynthetic process	IMP IMP: Inferred from mutant phenotype	17403930	MGI
involved in establishment of skin barrier	IMP IMP: Inferred from mutant phenotype	17403930	MGI
involved in linoleic acid metabolic process	IDA IDA: Inferred from direct assay	16129665	MGI
involved in protein lipidation	IMP IMP: Inferred from mutant phenotype	21558561	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	9837935	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

arachidonate 12-lipoxygenase, 12R-type

12R-lipoxygenase	epidermis-type lipoxygenase 12
epidermis-type lipoxygenase 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00615	ALOX12B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Alox12b	NCBI	NCBI:242

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