Slc19a2 - solute carrier family 19 (thiamine transporter), member 2 Gene

Mus musculus

Also known as DDA1; TRMA; THTR1; ThTr-1

Gene ID: 116914 | Gene type: protein coding

About Slc19a2

Summary

Enables thiamine transmembrane transporter activity. Involved in thiamine transmembrane transport. Acts upstream of or within thiamine transport. Located in plasma membrane. Is expressed in embryo; liver; and skeletal muscle. Used to study thiamine-responsive megaloblastic anemia syndrome. Human ortholog(s) of this gene implicated in diabetes mellitus; megaloblastic anemia; and thiamine-responsive megaloblastic anemia syndrome. Orthologous to human SLC19A2 (solute carrier family 19 member 2). [provided by Alliance of Genome Resources, Apr 2022]

Slc19a2 Products(2)

mRNA	Protein	Name
NM_001276455.1	NP_001263384.1	thiamine transporter 1 isoform b
NM_054087.3	NP_473428.1	thiamine transporter 1 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables thiamine transmembrane transporter activity	IDA IDA: Inferred from direct assay	11481326	MGI
enables thiamine transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	12393806	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in pyridoxine transport	IDA IDA: Inferred from direct assay	35512554	MGI
involved in spermatogenesis	IMP IMP: Inferred from mutant phenotype	14567973	MGI
involved in thiamine diphosphate biosynthetic process	IDA IDA: Inferred from direct assay	8186267	MGI
involved in thiamine transmembrane transport	IDA IDA: Inferred from direct assay	24961373	MGI
involved in thiamine transmembrane transport	IMP IMP: Inferred from mutant phenotype	19879271	MGI
acts upstream of or within thiamine transport	IDA IDA: Inferred from direct assay	11481326	MGI
involved in thiamine transport	IDA IDA: Inferred from direct assay	11592824	MGI
involved in thiamine transport	IMP IMP: Inferred from mutant phenotype	12393806	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in plasma membrane	IDA IDA: Inferred from direct assay	22194418	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	11481326	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

thiamine transporter 1

solute carrier family 19 member 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13048	SLC19A2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc19a2	NCBI	NCBI:10560

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