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Alx4 - aristaless-like homeobox 4 Gene

Also Known as lst

Species: Mus musculus

Gene Type: protein coding

Gene ID: 11695

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; HMG box domain binding activity; and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including embryonic limb morphogenesis; embryonic skeletal system morphogenesis; and roof of mouth development. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; embryo mesenchyme; genitourinary system; integumental system; and sensory organ. Used to study parietal foramina. Human ortholog(s) of this gene implicated in craniosynostosis and parietal foramina. Orthologous to human ALX4 (ALX homeobox 4). [provided by Alliance of Genome Resources, Apr 2022]

Alx4 Products (1)

mRNA	Protein	Name
NM_007442.3	NP_031468.1	homeobox protein aristaless-like 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	9847249	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	9786416	MGI
enables HMG box domain binding	IPI IPI: Inferred from physical interaction	16582099	MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	9847249	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9786416	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	9786416	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within anterior/posterior pattern specification	IGI IGI: Inferred from genetic interaction	9847249	MGI
acts upstream of or within anterior/posterior pattern specification	IMP IMP: Inferred from mutant phenotype	9374397	MGI
acts upstream of or within digestive tract development	IMP IMP: Inferred from mutant phenotype	9268572	MGI
acts upstream of or within embryonic digit morphogenesis	IGI IGI: Inferred from genetic interaction	9272948	MGI
acts upstream of or within embryonic digit morphogenesis	IMP IMP: Inferred from mutant phenotype	9268572	MGI
acts upstream of or within embryonic forelimb morphogenesis	IGI IGI: Inferred from genetic interaction	11641221	MGI
acts upstream of or within embryonic hindlimb morphogenesis	IGI IGI: Inferred from genetic interaction	11641221	MGI
acts upstream of or within embryonic skeletal system morphogenesis	IGI IGI: Inferred from genetic interaction	9847249	MGI
acts upstream of or within embryonic skeletal system morphogenesis	IMP IMP: Inferred from mutant phenotype	15728667	MGI
acts upstream of or within limb morphogenesis	IGI IGI: Inferred from genetic interaction	9847249	MGI
acts upstream of or within limb morphogenesis	IMP IMP: Inferred from mutant phenotype	9374397	MGI
acts upstream of or within muscle organ development	IMP IMP: Inferred from mutant phenotype	9374397	MGI
acts upstream of or within pattern specification process	IGI IGI: Inferred from genetic interaction	11641221	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9786416	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9847249	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	9847249	MGI
acts upstream of or within post-embryonic development	IMP IMP: Inferred from mutant phenotype	9268572	MGI
acts upstream of or within regulation of apoptotic process	IGI IGI: Inferred from genetic interaction	11641221	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11696550	MGI
acts upstream of or within roof of mouth development	IGI IGI: Inferred from genetic interaction	9847249	MGI
acts upstream of or within skeletal system morphogenesis	IMP IMP: Inferred from mutant phenotype	9374397	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	9374397	MGI
part of transcription regulator complex	IDA IDA: Inferred from direct assay	9847249	MGI
part of transcription regulator complex	IPI IPI: Inferred from physical interaction	11696550	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
homeobox protein aristaless-like 4	ALX-4 Aristaless-like 4 Strong's luxoid aristaless 4

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00638	ALX4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Alx4	NCBI	NCBI:60529