Ambn - ameloblastin Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11698

Summary

This gene encodes an extracellular matrix glycoprotein that is involved in the formation of dental enamel. Mice lacking the encoded protein fail to undergo normal ameloblast differentiation and develop enamel. Mice overproducing the product of this gene develop thinner and more porous enamel, with disrupted rod patterns and abnormal crystallites. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2014]

Ambn Products (2)

mRNA Protein Name
NM_001303431.1 NP_001290360.1 ameloblastin isoform 1 precursor
NM_009664.2 NP_033794.1 ameloblastin isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables growth factor activity IMP
IMP: Inferred from mutant phenotype
16674693 MGI
Biological Process GO Annotation Evidence References Source
involved in cell adhesion IMP
IMP: Inferred from mutant phenotype
16674693 MGI
involved in regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
16674693 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ameloblastin

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00641 AMBN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17485 Ambn Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23943 Ambn Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ambn NCBI NCBI:258