Eif2b4 - eukaryotic translation initiation factor 2B subunit delta Gene

Rattus norvegicus

Also known as Eif2b

Gene ID: 117019 | Gene type: protein coding

About Eif2b4

Summary

Enables translation initiation factor binding activity. Contributes to guanyl-nucleotide exchange factor activity. Involved in several processes, including hippocampus development; negative regulation of guanyl-nucleotide exchange factor activity; and response to glucose. Part of eukaryotic translation initiation factor 2B complex. Human ortholog(s) of this gene implicated in leukoencephalopathy with vanishing white matter. Orthologous to human EIF2B4 (eukaryotic translation initiation factor 2B subunit delta). [provided by Alliance of Genome Resources, Apr 2022]

Eif2b4 Products(1)

mRNA	Protein	Name
NM_053950.1	NP_446402.1	translation initiation factor eIF-2B subunit delta

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
contributes to guanyl-nucleotide exchange factor activity	IDA IDA: Inferred from direct assay	9582312	RGD
enables guanyl-nucleotide exchange factor activity	IDA IDA: Inferred from direct assay	9139680	RGD
enables translation initiation factor binding	IDA IDA: Inferred from direct assay	9446619	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in hippocampus development	IEP IEP: Inferred from expression pattern	12850562	RGD
involved in negative regulation of guanyl-nucleotide exchange factor activity	IDA IDA: Inferred from direct assay	9582312	RGD
involved in response to glucose	IDA IDA: Inferred from direct assay	8567668	RGD
involved in response to heat	IDA IDA: Inferred from direct assay	9341116	RGD
involved in response to peptide hormone	IDA IDA: Inferred from direct assay	8430778	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
part of eukaryotic translation initiation factor 2B complex	IDA IDA: Inferred from direct assay	9139680	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

translation initiation factor eIF-2B subunit delta

eIF-2B GDP-GTP exchange factor subunit delta	eukaryotic translation initiation factor 2B subunit 4
eukaryotic translation initiation factor 2B, subunit 4 delta

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-183704	ISR activator-5		/	Unkown
HY-RS04251	EIF2B4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Eif2b4	NCBI	NCBI:8890

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