Ptf1a - pancreas associated transcription factor 1a Gene

Rattus norvegicus

Gene ID: 117034 | Gene type: protein coding

About Ptf1a

Summary

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in exocrine pancreas development and regulation of transcription, DNA-templated. Located in cytoplasm and nucleus. Part of transcription regulator complex. Human ortholog(s) of this gene implicated in pancreatic agenesis. Orthologous to human PTF1A (pancreas associated transcription factor 1a). [provided by Alliance of Genome Resources, Apr 2022]

Ptf1a Products(1)

mRNA	Protein	Name
NM_053964.2	NP_446416.1	pancreas transcription factor 1 subunit alpha

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	2788241	RGD
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	1840677	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in exocrine pancreas development	IDA IDA: Inferred from direct assay	10768861	RGD
involved in regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	2788241	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	1720355	RGD
located in nucleus	IDA IDA: Inferred from direct assay	1720355	RGD
part of transcription regulator complex	IDA IDA: Inferred from direct assay	1720355	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

pancreas transcription factor 1 subunit alpha

PTF1-p48	bHLH transcription factor p48
p48 DNA-binding subunit of transcription factor PTF1	pancreas specific transcription factor, 1a

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11367	PTF1A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ptf1a	NCBI	NCBI:256297

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