Amelx - amelogenin, X-linked Gene

Also Known as Amg; ALGN; AMGL; AMGX; Amel; LRAP; Rgsc888

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11704

Summary

Enables several functions, including growth factor activity; hydroxyapatite binding activity; and metal ion binding activity. Involved in cell adhesion; enamel mineralization; and regulation of cell population proliferation. Acts upstream of or within odontogenesis of dentin-containing tooth. Located in basement membrane; cell surface; and supramolecular complex. Part of protein-containing complex. Is expressed in several structures, including connective tissue; eye; jaw; nervous system; and skeleton. Used to study amelogenesis imperfecta type 1E. Human ortholog(s) of this gene implicated in amelogenesis imperfecta and amelogenesis imperfecta type 1E. Orthologous to several human genes including AMELX (amelogenin X-linked). [provided by Alliance of Genome Resources, Apr 2022]

Amelx Products (3)

mRNA Protein Name
NM_001081978.2 NP_001075447.1 amelogenin, X isoform isoform 1 precursor
NM_001290371.1 NP_001277300.1 amelogenin, X isoform isoform 3 precursor
NM_009666.4 NP_033796.1 amelogenin, X isoform isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium ion binding IDA
IDA: Inferred from direct assay
19086270 MGI
enables growth factor activity IMP
IMP: Inferred from mutant phenotype
16674693 MGI
enables hydroxyapatite binding IDA
IDA: Inferred from direct assay
11852235 MGI
enables identical protein binding IDA
IDA: Inferred from direct assay
23896516 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
9041053 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11063033 MGI
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
19086270 MGI
enables sodium ion binding IDA
IDA: Inferred from direct assay
19086270 MGI
Biological Process GO Annotation Evidence References Source
involved in amelogenesis IDA
IDA: Inferred from direct assay
26403673 MGI
involved in cell adhesion IMP
IMP: Inferred from mutant phenotype
16674693 MGI
involved in enamel mineralization IDA
IDA: Inferred from direct assay
26403673 MGI
involved in odontogenesis of dentin-containing tooth IEP
IEP: Inferred from expression pattern
16674683 MGI
involved in regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
16674693 MGI
involved in tooth mineralization IMP
IMP: Inferred from mutant phenotype
11406633 MGI
Cellular Component GO Annotation Evidence References Source
located in basement membrane IDA
IDA: Inferred from direct assay
18757743 MGI
located in cell surface IMP
IMP: Inferred from mutant phenotype
16674683 MGI
part of protein-containing complex IDA
IDA: Inferred from direct assay
19086270 MGI
located in supramolecular complex IDA
IDA: Inferred from direct assay
20304108 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

amelogenin, X isoform

  • amelogenin X chromosome

  • enamel matrix protein

  • leucine-rich amelogenin peptide

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00647 AMELX Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19982 Amelx Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26486 Amelx Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Amelx NCBI NCBI:265